SU6656

SU6656 価格

SU6656 化学特性,用途語,生産方法

• 説明

  The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC₅₀ = 280, 20, 130, 170 nM, respectively). It weakly inhibits some other kinases when used at >10 μM. SU6656 has been used to study the role of Src kinases in cell growth and development in diverse processes, including nervous system development, fibrosis, and cancer.

• 使用

  SU 6656 is a small molecule selective inhibitor of the Src kinase family and induces caspase-independant cancer cell death.

• 一般的な説明

  A potent, cell-permeable, reversible, and ATP-competitive inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC₅₀ = 280 nM) as well as closely related kinases Fyn (IC₅₀ = 170 nM), Yes (IC₅₀ = 20 nM) and Lyn (IC₅₀ = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC₅₀ = 6.88 μM). Does not affect the activity of PDGF-β receptor kinase (IC₅₀ ≥10 μM) and IGF-1 receptor kinase (IC₅₀ ≥20 μM).

SU6656 生産企業

Global(91)Suppliers

SU6656 スペクトルデータ(¹HNMR)

330161-87-0, SU6656 キーワード