3,3'-ジアミノベンジジン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H302：飲み込むと有害

  H319：強い眼刺激

  H341：遺伝性疾患のおそれの疑い

  H350：発がんのおそれ

• 注意書き

  P202：全ての安全注意を読み理解するまで取り扱わないこ と。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

3,3'-ジアミノベンジジン 価格

3,3'-ジアミノベンジジン 化学特性,用途語,生産方法

• 外観

  うすい黄色～褐色粉末～結晶

• 外観

  白色～褐色粉末～結晶

• 溶解性

  エタノールに溶け、水にほとんど溶けない。

• 解説

  3,3'-ジアミノベンジジン,板状晶．融点178～180 ℃．空気中で酸化されてしだいに褐色となる．各種耐熱ポリマーの原料であり，イソフタル酸と縮合重合させたポリ(ベンゾイミダゾール)の合成や，そのほか全芳香族ポリマーの成分として用いられる．

  森北出版「化学辞典（第2版)
  

• 用途

  有機合成用試薬。

• 製造

  ベンジジンをニトロ化すると得られる3,3′-ジニトロベンジジンを還元すれば得られる．

• 説明

  3,3'-Diaminobenzidine (DAB) is a precursor to polybenzimidazole. DAB is frequently used in the immunohistochemical staining of nucleic acids and proteins. It can also be used to detect fingerprints in blood because that it can be oxidized by hydrogen peroxide in the presence of hemoglobin to give a dark-brown color.

• 化学的特性

  Off-white to brown solid.

• 使用

  3,3'-Diaminobenzidine is used as peroxidase substrate and a reagent for spectrophotometric determination of selenium. DAB is used for the immunohistochemical staining of nucleic acids and proteins. As a dark brown dye, was used as an antibody-specific stain to identify the paired antibodies in breast tissue. It may be used for the synthesis of a useful, linear, Schiff-base coordination polymer.

• 定義

  ChEBI: 3,3'-diaminobenzidine is a member of the class of biphenyls that is benzidine in which one of the hydrogens ortho to each of the amino groups has been replaced by an amino group. It has a role as a histological dye. It is a member of biphenyls and a substituted aniline.

• 主な応用

  3,3'-Diaminobenzidine is used for preparation of high-strength material such as nucleic acid stain and resistance high-temperature polymers such as bullet-proof vests.?

• 合成

  3,3'-Diaminobenzidine can be synthesized by treating 3, 3'-dichlorobenzidine with ammonia in the presence of copper catalyst at high temperature and pressure.

• 主な応用

  3,3',4,4' -Tetraaminodiphenyl (3,3'-Diaminobenzidine) is suitable for the production of fibers based on polybenzimidazole. These fibers are resistant to high temperature and to chemicals. Fabrics made from them do not burn, do not melt in contact with a flame, and do not become hard when carbonized. They are suitable for the production of protective clothing and flue–gas filters and as substitutes for asbestos.

• 製造方法

  15 kg of 98.5% pure 3,3'-dinitro-4,4'-diaminobiphenyl tide product and 45 kg of methanol,0.075 kg of palladium carbon is mixed, and hydrogen gas of 0.85-0.9 MPa is introduced at 55-60 ° C, and stirred for 3 hours.At the end of the reaction, the catalyst was recovered, methanol was recovered, 30 kg of water was added, and the mixture was centrifuged and dried to obtain 9.3 kg of 3,3'-Diaminobenzidine having a purity of 99.3%.The yield was 90.6% (based on 3,3'-dinitro-4,4'-diacetylaminobiphenyl).

• 安全性プロファイル

  Suspected carcinogen withexperimental tumorigenic data. Moderately toxic byingestion. Mutation data reported. When heated todecomposition it emits toxic fumes of NOx.

• 参考文献

  3,3′-Diaminobenzidine staining interferes with PCR-based DNA analysis
  DOI:10.1038/s41598-018-19745-9
  Transition metal complexes of novel binuclear Schiff base derived from 3,3′-diaminobenzidine: synthesis, characterization, thermal behavior, DFT, antimicrobial and molecular docking studies
  DOI:10.1080/00958972.2020.1752372
  3, 3′-Diaminobenzidine with dual o-phenylenediamine groups: two in one enables visual colorimetric detection of nitric oxide
  DOI:10.1007/s00216-020-02482-2
  A new sensitive colorimetric assay for peroxidase using 3,3'-diaminobenzidine as hydrogen donor.
  DOI:10.1016/0003-2697(73)90144-9

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