AMG-9810 化学構造式

AMG-9810

化学名:AMG-9810

CAS番号.545395-94-6

英語名:AMG 9810

CBNumberCB0306302

MFC21H23NO3

MW337.41

MOL File545395-94-6.mol

别名

(E)-N-(2,3-ジヒドロ-1,4-ベンゾジオキシン-6-イル)-3-(4-tert-ブチルフェニル)アクリルアミド

(2E)-3-(4-tert-ブチルフェニル)-N-(2,3-ジヒドロ-1,4-ベンゾジオキシン-6-イル)プロパ-2-エンアミド

AMG-9810

AMG-9810物理性質

沸点	512.5±50.0 °C(Predicted)
比重(密度)	1.175±0.06 g/cm3(Predicted)
貯蔵温度	2-8°C
溶解性	DMSO：>5mg/mL
酸解離定数(Pka)	12.22±0.20(Predicted)
外見	粉
色	白からベージュ
InChI	1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+
InChIKey	GZTFUVZVLYUPRG-IZZDOVSWSA-N
SMILES	CC(C)(C)c1ccc(\C=C\C(=O)Nc2ccc3OCCOc3c2)cc1

安全性情報

主な危険性	Xn
Rフレーズ	22
WGK Germany	3
ストレージクラス	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Aquatic Chronic 4

危険有害性情報のコード(GHS)

AMG-9810 価格

製品番号	包装	価格	製品説明	購入
富士フイルム和光純薬株式会社(wako) W01TOC2316	10mg	￥58000		購入
富士フイルム和光純薬株式会社(wako) W01TOC2316	50mg	￥245000		購入
Sigma-Aldrich Japan A2731	10mg	￥36300	≥98% (HPLC), powder	購入
Sigma-Aldrich Japan A2731	50mg	￥136000	≥98% (HPLC), powder	購入
富士フイルム和光純薬株式会社(wako) W01W0101-2507	10mg	￥14500	98.0+% (HPLC)	購入

AMG-9810 化学特性,用途語,生産方法

外観
白色～褐色, 結晶～粉末
溶解性
エタノール及びアセトンに溶け、水にほとんど溶けない。
説明
AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC₅₀s = 24.5 and 85.6 nM for human and rat, respectively). Additionally, it has been shown to compete with other modes of TRPV1 activation, including protons (IC₅₀s = 92.7 and 294 nM for human and rat, respectively), heat (IC₅₀s = 15.8 and 21 nM for human and rat, respectively), and the endogenous ligands: anandamide, N-arachidonyl dopamine (IC₅₀s = 8.5 and 260 nM for human and rat, respectively), and oleoyldopamine. In a rat model of inflammatory pain induced by intraplantar injection of complete Freund’s adjuvant, 30-100 mg/kg AMG 9810 reverses thermal and mechanical hyperalgesia.
使用
AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat, respectively). Additionally, it has been shown to compete with other modes of TRPV1 activation, including protons (IC50s = 92.7 and 294 nM for human and rat, respectively), heat (IC50s = 15.8 and 21 nM for human and rat, respectively), and the endogenous ligands: anandamide, N-arachidonyl dopamine (IC50s = 8.5 and 260 nM for human and rat, respectively), and oleoyldopamine. In a rat model of inflammatory pain induced by intraplantar injection of complete Freund’s adjuvant, 30-100 mg/kg AMG 9810 reverses thermal and mechanical hyperalgesia.[Cayman Chemical]
生物活性
AMG 9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC 50 = 17 nM). Inhibits capsaicin-, proton-, heat- and endogenous ligand-induced activation of human and rat recombinant TRPV1 receptors. Displays antihyperalgesic properties in a rat model of inflammatory pain.

AMG-9810 生産企業

AMG-9810 スペクトルデータ(¹HNMR)

545395-94-6, AMG-9810 キーワード

Send Inquriy

AMG-9810

危険有害性情報のコード(GHS)

AMG-9810 価格

AMG-9810 化学特性,用途語,生産方法

AMG-9810 生産企業

AMG-9810 スペクトルデータ(1HNMR)

545395-94-6, AMG-9810 キーワード

AMG-9810 スペクトルデータ(¹HNMR)