GW1929 水和物

化学名:GW1929 水和物

CAS番号.196808-24-9

英語名:GW1929

CBNumberCB0259985

MFC30H29N3O4

MW495.57

MOL File196808-24-9.mol

别名

GW1929 水和物

(2S)-2-[(2-ベンゾイルフェニル)アミノ]-3-(4-{2-[メチル(ピリジン-2-イル)アミノ]エトキシ}フェニル)プロパン酸

N-(2-ベンゾイルフェニル)-O-[2-[メチル(2-ピリジル)アミノ]エチル]-L-チロシン

GW1929 水和物物理性質

沸点	749.2±60.0 °C(Predicted)
比重(密度)	1.264±0.06 g/cm3(Predicted)
貯蔵温度	Desiccate at +4°C
溶解性	DMSO: 20 mg/mL
外見	個体
酸解離定数(Pka)	3.91±0.10(Predicted)
色	黄色
InChIKey	QTQMRBZOBKYXCG-MHZLTWQESA-N
SMILES	C(O)(=O)[C@H](CC1=CC=C(OCCN(C)C2=NC=CC=C2)C=C1)NC1=CC=CC=C1C(=O)C1=CC=CC=C1

安全性情報

WGK Germany	3
ストレージクラス	11 - Combustible Solids

GW1929 水和物価格

製品番号	包装	価格	製品説明	購入
Sigma-Aldrich Japan G5668	5mg	￥46200	GW1929 水和物 >98% (HPLC), solid	購入
Sigma-Aldrich Japan G5668	25mg	￥137000	GW1929 水和物 >98% (HPLC), solid	購入

GW1929 水和物化学特性,用途語,生産方法

説明
Peroxisome proliferator-activated receptor (PPAR) γ is a nuclear receptor that, when activated, regulates fatty acid storage and glucose metabolism. The best known class of PPARγ ligands are the thiazolidinediones, including troglitazone and rosiglitazone. GW 1929 is a non-thiazolidinedione activator of PPARγ that binds with a Ki value of 1.4 nM, with greater than 1,000-fold selectivity over other PPAR subtypes. It has anti-hyperglycemic and anti-hyperlipidemic activity when given orally in mouse and rat models of type 2 diabetes. Both in vitro and in vivo effects of GW 1929 on PPARγ greatly exceed those produced by troglitazone. In addition, GW 1929 has neuroprotective effects in global cerebral ischemic-reperfusion injury that are related to reduced inflammation and apoptotic DNA fragmentation.
使用
GW1929 has been used as a peroxisome proliferator-activated receptor γ (PPARγ) ligand:
Investigating its impact on the expression of plant homeodomain finger protein 16 (Phf16) and patatin-like phospholipase domain containing 3 (Pnpla3) in relation to adipogenesis.
Examining its influence on complement component 3 (C3) gene expression in human hepatoma cells.
Activating PPARγ in human breast cancer cells.
生物活性
Highly selective orally active peroxisome proliferator-activated receptor (PPAR) γ agonist (pEC 50 values are 8.05, < 4 and < 4 for human PPAR γ , PPAR α and PPAR δ receptors respectively). Decreases glucose, fatty acid and triglyceride levels following oral administration in vivo .
参考文献
[1] heppner tj,bonev ad,eckman dm,gomez mf,petkov gv,nelson mt. novel ppargamma agonists gi 262570, gw 7845, gw 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries. pharmacology.2005 jan;73(1):15-22.
[2] kaundal rk,sharma ss. ameliorative effects of gw1929, a nonthiazolidinedione pparγ agonist, on inflammation and apoptosis in focal cerebral ischemic-reperfusion injury. curr neurovasc res.2011 aug 1;8(3):236-45.
[3] GW1929: a nonthiazolidinedione PPARγ agonist, ameliorates neurological damage in global cerebral ischemic-reperfusion injury through reduction in inflammation and DNA fragmentation DOI: 10.1016/j.bbr.2010.09.001

GW1929 水和物生産企業

GW1929 水和物スペクトルデータ(¹HNMR)

196808-24-9, GW1929 水和物キーワード

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GW1929 水和物

GW1929 水和物 価格

GW1929 水和物 化学特性,用途語,生産方法

GW1929 水和物 生産企業

GW1929 水和物 スペクトルデータ(1HNMR)

196808-24-9, GW1929 水和物 キーワード

GW1929 水和物価格

GW1929 水和物化学特性,用途語,生産方法

GW1929 水和物生産企業

GW1929 水和物スペクトルデータ(¹HNMR)

196808-24-9, GW1929 水和物キーワード