エグアレンナトリウム水和物

エグアレンナトリウム水和物 化学特性,用途語,生産方法

• 効能

  消化性潰瘍薬

• 商品名

  アズロキサ (寿製薬); アズロキサ (寿製薬)

• 説明

  Egualen, formulated as a sodium salt, was marketed in Japan for the treatment of gastric ulcers and gastritis. It is a water-soluble sodium sulfonate analog of guaiazulene, a natural azulene with anti-ulcer activity. Egualen can be prepared from an 7- isopropyl azulen-2-yl carboxylate by successive 3-acetylation, reduction, decarboxylation and finally, sulfonylation in l-position. The mechanism of action is not well defined; egualen is a weak inhibitor of the enzyme system H⁺/K⁺ ATPase and a weak antagonist of prostanoid receptors; concomitantly, it was shown to possess some anti-inflammatory properties. In animal models of gastric ulcers induced with cortisone or acetic acid, oral treatment with egualen sodium promoted healing of ulcers and, at higher doses, mucosal regeneration. The data available from clinical studies for egualen are limited; in one trial, the combination of egualen sodium and cimetidine administered to patients with unhealing gastric ulcers produced an appreciable rate of healing without any adverse events.

• 使用

  Egualen Sodium can be used in combination of anti-ulcer drugs and gastric acid secretion inhibitors to treat digestive tract diseases.

• 定義

  ChEBI: An organic sodium salt having 3-ethyl-7-isopropylazulene-1-sulfonate as the counterion. Used for treatment of gastric ulcers.