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Aliskiren

Aliskiren Structure
Aliskiren
  • CAS No.173334-57-1
  • Chemical Name:Aliskiren
  • CBNumber:CB9966226
  • Molecular Formula:C30H53N3O6
  • Formula Weight:551.76
  • MOL File:173334-57-1.mol
Aliskiren Property
  • Melting point 98-99 °C
  • Boiling point 748.4±60.0 °C(Predicted)
  • Density 1.067±0.06 g/cm3(Predicted)
  • storage temp. Inert atmosphere,Store in freezer, under -20°C
  • solubility DMSO : 100 mg/mL (181.24 mM; Need ultrasonic)
  • form Powder
  • pka 9.49(at 25℃)
  • color White to light yellow
  • CAS DataBase Reference 173334-57-1(CAS DataBase Reference)
  • FDA UNII 502FWN4Q32
  • ATC code C09XA02
  • UNSPSC Code 12352200
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P264-P271-P280-P302+P352-P305+P351+P338
Aliskiren Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: CDS023114
  • Product name : Aliskiren
  • Purity: 
  • Packaging: 10MG
  • Price: ₹18023.63
  • Updated: 2022/06/14
  • Buy: Buy

Aliskiren Chemical Properties,Usage,Production

  • Description Aliskiren is a first-in-class antihypertensive drug that acts by direct inhibition of renin. It is indicated for oral administration either as monotherapy or in combination with other antihypertensive agents. Renin catalyzes the cleavage of angiotensin to form angiotensin I, the first and the rate-limiting step of the RAAS. The inhibition of renin by aliskiren results in reduced levels of angiotensin I, angiotensin II, and aldosterone, all of which contribute to the antihypertensive effect. RAAS modulators are among some of the most commonly prescribed antihypertensive agents to date.The most common side effect of aliskiren is diarrhea, particularly with doses higher than 300mg daily. Unlike ACE inhibition, direct inhibition of renin does not increase bradykinin levels. Elevated bradykinin levels are thought to be responsible for the angioderma and cough that occur commonly during treatment with ACE inhibitors. .
  • Originator Novartis (Switzerland)
  • Uses An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive
  • Uses liquid crystal intermediate
  • Definition ChEBI: A monomethoxybenzene compound having a 3-methoxypropoxy group at the 2-position and a multi-substituted branched alkyl substituent at the 4-position.
  • brand name Tekturna
  • General Description Aliskiren, (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2-methyl-propyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-propan-2-yl-nonanamide (Tekturna), is the first renin inhibitorintroduced into the U. S. market. It was approved by theFDA in 2007 for the management of hypertension.The trade name for aliskiren in the United Kingdom isRasilez.
Aliskiren Preparation Products And Raw materials
Raw materials
Preparation Products
Aliskiren Suppliers
Global(193)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29859
  • Advantage：58
Aliskiren Spectrum
173334-57-1, AliskirenRelated Search:
  • Aliskiren intermediates
  • Chemical Amines
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Chiral Reagents
  • Amines
  • API
  • 抑制剂
  • 药靶配体
  • FDA批准的配体
  • 化学试剂
  • 医药原料
  • 原料药
  • 降糖降压产品
  • 有机中间体
  • Antihypertensive抗高血压类
  • C30H53N3O6C4H4O4
  • C34H57N3O10
  • C30H53N3O6
  • C30H53N3O6HCl
  • 阿利吉伦·D6半富马酸盐
  • PERFEMIKER]阿利克仑,99%
  • 化合物 T22233
  • 阿利吉仑
  • (2S,4S,5S,7S)-5-氨基-N-(3-氨基-2,2-二甲基-3-氧代丙基)-4-羟基-2-异丙基-7-(4-甲氧基-3-(3-甲氧基丙氧基)苄基)-8-甲基壬酰胺
  • 阿里斯基伦
  • 阿立克仑
  • 阿利克仑游离碱
  • 阿利克仑
  • (2S,4S,5S,7S)-5-氨基-N-(2-氨基甲酰基-2-甲基丙基)-4-羟基-2-异丙基-7-[4-甲氧基-3-(3-甲氧基丙氧基)苄基]-8-甲基壬酰胺
  • 阿利克仑(抗高血压)
  • 阿利吉伦
  • 阿利吉仑D6
  • 阿利克伦(阿利吉伦)
  • 阿利吉仑游离碱
  • 173334-57-1
  • Aliskiren 100 μg/ml Acetonitrile
  • Aliskiren 99% CAS NO.173334-57-1
  • (2S,4S,5S,7S)-5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide
  • Aliskiren USP/EP/BP
  • Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-
  • CGP-60536; CGP60536; TEKTURNA;SPP 100
  • CS-201
  • CGP 60536;CGP60536B;SPP 100
  • 5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypr
  • Aliskiren, >=98%
  • 5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate
  • Aliskiren Base
  • (2S,4S,5S,7S)-7-(4-Methoxy-3-(3-Methoxypropoxy)benzyl)-5-aMino-N-(3-aMino-2,2-diMethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-8-MethylnonanaMide
  • Aliskiren (USAN)
  • Aliskiren (CGP 60536)
  • (2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-Methoxybenzyl)-5-aMino-N-(2-carbaMoyl-2-Methylpropyl)-4-hydroxy-2-isopropyl-8-MethylnonanaMide
  • ALISKIREN FREE BASE
  • (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide
  • (aS,S,dS,zS)-d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)--hydroxy-4-methoxy-3-(3-methoxypropoxy)-a,z-bis(1-methylethyl)benzeneoctanamide
  • Tekturna
  • SPP 100
  • Rasilez

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