ChemicalBook > CAS DataBase List > S-(hydrogen malonyl)coenzyme A
S-(hydrogen malonyl)coenzyme A
S-(hydrogen malonyl)coenzyme A
- CAS No.524-14-1
- Chemical Name:S-(hydrogen malonyl)coenzyme A
- CBNumber:CB9908893
- Molecular Formula:C24H38N7O19P3S
- Formula Weight:853.58
- MOL File:524-14-1.mol
S-(hydrogen malonyl)coenzyme A Property
- Density 1.95±0.1 g/cm3(Predicted)
- pka 1.16±0.50(Predicted)
- FDA UNII LNB9YCJ9F9
- Symbol(GHS)
- Signal word
- Hazard statements
- Precautionary statements
S-(hydrogen malonyl)coenzyme A Chemical Properties,Usage,Production
- Uses Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1[1][2].
- Definition ChEBI: The S-malonyl derivative of coenzyme A.
- IC 50 Human Endogenous Metabolite
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References
[1] Folmes CD, et L. Role of malonyl-CoA in heart disease and the hypothalamic control of obesity. Cardiovasc Res. 2007 Jan 15;73(2):278-87. DOI:10.1016/j.cardiores.2006.10.008
[2] Thupari JN, et al. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun. 2001 Jul 13;285(2):217-23. DOI:10.1006/bbrc.2001.5146
[3] Zammit VA. Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro. Biochem J. 1983 Mar 15;210(3):953-6. DOI:10.1042/bj2100953
S-(hydrogen malonyl)coenzyme A Preparation Products And Raw materials
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524-14-1, S-(hydrogen malonyl)coenzyme ARelated Search:
- 酶
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- 524-14-1
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