Hydroxy-PEG16-t-butyl ester
- Product NameHydroxy-PEG16-t-butyl ester
- CAS2592433-80-0
- CBNumberCB99023924
- MFC39H78O19
- MW851.03
- MDL NumberMFCD21363264
- MOL File2592433-80-0.mol
Chemical Properties
| Boiling point: | 774.9±55.0 °C(Predicted) |
| Density | 1.097±0.06 g/cm3(Predicted) |
| pka | 14.36±0.10(Predicted) |
Hydroxy-PEG16-t-butyl ester Chemical Properties,Usage,Production
Uses
Hydroxy-PEG16-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].Biological Activity
Hydroxy-PEG16-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].IC 50
PEGs; Alkyl/etherReferences
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.Hydroxy-PEG16-t-butyl ester Suppliers
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