Description
L319, also known as O-8670, is a novel ionizable biodegradable lipid for delivery of short interfering RNAs via lipid nanoparticles. L319-LPN displays rapid elimination with pKa of 6.38 and also shows well tolerated up to 10mg/kg.
Uses
L319 is an ionizable cationic lipidoid and can be used for synthetic liposomes, from the patent WO-2011153493-A2, compound 1[1].
References
[1] Biodegradable lipids for the delivery of active agents. WO2011153493A2
[2] Maier MA, Jayaraman M, Matsuda S, et al. Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics.Mol Ther. 2013;21(8):1570-1578. DOI:
10.1038/mt.2013.124