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Celiprolol hydrochloride

Celiprolol hydrochloride Structure
Celiprolol hydrochloride
  • CAS No.57470-78-7
  • Chemical Name:Celiprolol hydrochloride
  • CBNumber:CB9773826
  • Molecular Formula:C20H34ClN3O4
  • Formula Weight:415.95
  • MOL File:57470-78-7.mol
Celiprolol hydrochloride Property
  • Melting point 197-200°C (dec.)
  • RTECS YR6560000
  • storage temp. Refrigerator
  • solubility Freely soluble in water and in methanol, soluble in ethanol (96 per cent), very slightly soluble in methylene chloride.
  • form Solid
  • color White to Off-White
  • Water Solubility Soluble in ethanol, methanol and water
  • CAS DataBase Reference 57470-78-7(CAS DataBase Reference)
  • FDA UNII G1M3398594
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Toxicity :LD50 in male mice, rats (mg/kg): 56.2, 68.3 i.v.; 1834, 3826 orally (Wendtlandt, Pittner)
  • NFPA 704:
    0
    1 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H303
  • Precautionary statements P270-P301+P312-P403-P501c
Celiprolol hydrochloride Price More Price(1)
  • Brand: ALFA India
  • Product number: ALF-J65943-MA
  • Product name : Celiprolol hydrochloride
  • Purity: 
  • Packaging: 10mg
  • Price: ₹14685
  • Updated: 2022/05/26
  • Buy: Buy

Celiprolol hydrochloride Chemical Properties,Usage,Production

  • Description Celiprolol hydrochloride is a once-daily, cardioselective β-adrenergic blocker useful in the management of hypertension, angina pectoris and hyperkinetic heart syndrome. It is also being evaluated in glaucoma.
  • Chemical Properties White Crystalline Solid
  • Originator Chemie Linz (Austria)
  • Uses antihypertensive antianginal;beta blocker
  • Uses Cardioselective β1-adrenergic blocker. Antihypertensive, antianginal.
  • Uses Cardioselective 1-adrenergic blocker. Antihypertensive, antianginal
  • Definition ChEBI: Celiprolol hydrochloride is an aromatic ketone.
  • brand name Selecor (Rhone-Poulenc Rorer);SELECTOL.
  • in vitro the ability of celiprolol to induce the regulation of beta adrenergic receptors was investigated in s49 lymphoma cells. results showed that celiprolol did not stimulate adenylate cyclase in membranes from wild-type (wt) s49 cells or induced the sequestration of beta adrenergic receptors on intact cells. moreover, exposure of wt s49 cells to celiprolol led to the loss of around half of the total cellular beta adrenergic receptors [1].
  • in vivo in a previous study, japanese white rabbits underwent 30 min of ischemia and 48 h of reperfusion. celiprolol was administered 20 min before ischemia with or without pretreatment with n(omega)-nitro-l-arginine methylester (l-name) or 5-hydroxydecanoic acid sodium salt (5-hd). results showed that celiprolol could significantly reduce the infarct size dose-dependently. the infarct size-reducing effect of celiprolol was found to be completely blocked by l-name but not by 5-hd. in addition, celiprolol could increase the myocardial interstitial levels of nox and reduce the intensity of myocardium staining [2].
  • Drug interactions Potentially hazardous interactions with other drugs
    Anaesthetics: enhanced hypotensive effect.
    Analgesics: NSAIDs antagonise hypotensive effect.
    Anti-arrhythmics: increased risk of myocardial depression and bradycardia; increased risk of bradycardia, myocardial depression and AV block with amiodarone; increased risk of myocardial depression and bradycardia with flecainide
    Antidepressants: enhanced hypotensive effect with MAOIs.
    Antihypertensives; enhanced hypotensive effect; increased risk of withdrawal hypertension with clonidine; increased risk of first dose hypotensive effect with post-synaptic alpha-blockers such as prazosin.
    Antimalarials: increased risk of bradycardia with mefloquine.
    Antipsychotics enhanced hypotensive effect with phenothiazines
    .Calcium-channel blockers: increased risk of bradycardia and AV block with diltiazem; hypotension and heart failure possible with nifedipine and nisoldipine; asystole, severe hypotension and heart failure with verapamil.
    Cytotoxics: possible increased risk of bradycardia with crizotinib.
    Diuretics: enhanced hypotensive effect.
    Fingolimod: possibly increased risk of bradycardia.Moxisylyte: possible severe postural hypotension.
    Sympathomimetics: severe hypertension with adrenaline and noradrenaline and possibly with dobutamine.
  • Metabolism Metabolism of celiprolol is minimal and it is mainly excreted unchanged in the urine (50%) and faeces (50%)
  • References [1] reynolds ee, molinoff pb. down regulation of beta adrenergic receptors in s49 lymphoma cells induced by atypical agonists. j pharmacol exp ther. 1986 dec;239(3):654-60.
    [2] chen, x. ,minatoguchi, s.,arai, m., et al. celiprolol, a selective β1-blocker, reduces the infarct size through production of nitric oxide in a rabbit model of myocardial infarction. circulation journal 71(4), 574-579 (2007).
    [3] ong kt et al. effect of celiprolol on prevention of cardiovascular events in vascular ehlers-danlos syndrome: a prospective randomised, open, blinded-endpoints trial. lancet. 2010 oct 30;376(9751):1476-84.
Celiprolol hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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Celiprolol hydrochloride Spectrum
57470-78-7, Celiprolol hydrochlorideRelated Search:
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  • 盐酸塞利洛尔（标准品）
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  • C20H33N3O4HCl
  • C20H34ClN3O4
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  • 2,2,3,3,4,4,5,5,6-九溴联苯醚
  • 57470-78-7
  • Celiprolol hydrochloride, Cardioselective beta1 adrenoceptor antagonist
  • Leuprorelin Impurity 19
  • Celipolol Hcl
  • 4'-DDE
  • Celiprolol HydrochlorideQ: What is Celiprolol Hydrochloride Q: What is the CAS Number of Celiprolol Hydrochloride Q: What is the storage condition of Celiprolol Hydrochloride Q: What are the applications of Celiprolol Hydrochloride
  • Celiprolol hydrochloride USP/EP/BP
  • 3-[3-Acetyl-4-[(2RS)-3-[(1,1-dimethylethyl)amino]-2- hydroxypropoxy]phenyl]-1,1-diethylurea hydrochloride.
  • Celiprolol for peak identification CRS
  • Celiprolol hydrochloride CRS
  • Celiprolol Hydrochloride Tablets
  • 2,2',3,3',4,4',5,5',6-Nonabromodiphenyl ether,50 ug/mL in Isooctane
  • clorhidratodeceliprolol
  • 3-(3-acetil-4-(3-tert-butilamino-2-hidroxipropoxi)fenil)-1,1-dietilureahcl
  • Urea,N'-[3-acetyl-4-[3-[(1,1-diMethylethyl)aMino]-2-hydroxypropoxy]phenyl]-N,N-diethyl-,hydrochloride (1:1)
  • Srontacs
  • Ceproblock
  • Celtop
  • N'-[3-Acetyl-4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-N,N-diethylurea Hydrochloride
  • CELERYSEEDEXTRACT
  • ST 1396
  • Selecor
  • REV 5320A
  • NSC 324509
  • Corliprol
  • Celectol
  • CELIPOLOLHYDROCHLORIDE(SUBJECTTOPATENTFREE)
  • Urea, N-3-acetyl-4-3-(1,1-dimethylethyl)amino-2-hydroxypropoxyphenyl-N,N-diethyl-, monohydrochloride
  • 3-[3-acetyl-4-[3-[(tert-butyl)amino]-2-hydroxypropoxy]phenyl]-1,1-diethyluronium chloride
  • Celipolol Hydrochloride
  • CELIPROLOL HYDROCHLORIDE
  • 3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea hydrochloride
  • celiprololhydrochlorid

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