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2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine

2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine Structure
2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine
  • CAS No.2055397-28-7
  • Chemical Name:2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine
  • CBNumber:CB94660414
  • Molecular Formula:C18H13F2N3O3S
  • Formula Weight:389.38
  • MOL File:2055397-28-7.mol
2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine Property
  • Density 1.414±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO:30.0(Max Conc. mg/mL);76.97(Max Conc. mM)
  • form A crystalline solid
  • pka 6.79±0.25(Predicted)
  • color Off-white to light yellow
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H290-H315-H319
  • Precautionary statements P264b-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364-P390-P406b-P501c
2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML3067
  • Product name : WM-1119
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹9093
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML3067
  • Product name : WM-1119
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹36707.58
  • Updated: 2022/06/14
  • Buy: Buy

2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine Chemical Properties,Usage,Production

  • Uses WM 1119 is a highly potent and selective inhibitor of lysine acetyltransferases, KAT6A and KAT6B.
  • Biological Activity WM-1119 is a potent and selective, acetyl coenzyme A (Acetyl-CoA)-competitive inhibitor against MYST family histone acetyltransferases KAT6A and KAT6B (KAT6B Kd = 2.1 nM by SPR, IC50 = 37 nM by activity assay; KAT7/5 Kd = 0.53/2.2 μM; no affinity toward 159 diverse biological targets). WM-1119 induces MEF G1 cell cycle arrest (1-10 μM), inhibits EMRK1184 lymphoma growth in cultures (IC50 = 250 nM) and in mice in vivo (50 mg/kg 3x or 4x i.p. per day).
  • in vivo

    By day 14, the cohorts that are treated four times per day with WM-1119 have arrested tumour growth, with the exception of one mouse that does not respond. Spleen weights in the WM-1119-treatment group (treated four times per day) are substantially lower than spleen weights in the vehicle-treated group. Treatment with WM-1119 three times per day leads to a significant reduction in tumour burden and spleen weight, but is not as effective as treatment four times per day. WM-1119 is well-tolerated; mice show no generalized ill effects and weight loss is not observed. The proportion and overall number of tumour cells is substantially reduced by WM-1119 treatment (four times per day)[1].

  • IC 50 MOZ/MORF
  • storage Store at +4°C
2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine Suppliers
Global(76)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
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2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine Spectrum
2055397-28-7, 2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazineRelated Search:
  • API
  • 抑制剂
  • 药靶配体
  • 杂化
  • 生物活性分子
  • 化合物WM-1119,10 MM DMSO 溶液
  • 苯甲酸,3-氟-5-(2-吡啶基)-,2-[(2-氟苯基)磺酰基]酰肼
  • WM 1119,KAT6A(MOZ)竞争性抑制剂
  • 化合物WM-1119
  • 2-氟-N'-(3-氟-5-(吡啶-2-基)苯甲酰基)苯磺酰肼
  • 2055397-28-7
  • WM-1119, 10 mM in DMSO
  • 2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
  • Histone Acetyltransferase,HATs,HAT,Inhibitor,WM 1119,inhibit,WM-1119
  • Benzoic acid, 3-fluoro-5-(2-pyridinyl)-, 2-[(3-fluorophenyl)sulfonyl]hydrazide
  • （WM-1119） 2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine
  • Benzoic acid, 3-fluoro-5-(2-pyridinyl)-, 2-[(2-fluorophenyl)sulfonyl]hydrazide
  • CS-2848
  • WM-1119;WM 1119;WM1119;KAT6A INHIBITOR; KAT6B INHIBITOR
  • WM-1110
  • WM-1119
  • 2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine

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