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CALCIMYCIN A23187 HEMIMAGNESIUM SALT

CALCIMYCIN A23187 HEMIMAGNESIUM SALT Structure
CALCIMYCIN A23187 HEMIMAGNESIUM SALT
  • CAS No.72124-77-7
  • Chemical Name:CALCIMYCIN A23187 HEMIMAGNESIUM SALT
  • CBNumber:CB9367461
  • Molecular Formula:C58H72MgN6O12
  • Formula Weight:1069.55
  • MOL File:72124-77-7.mol
CALCIMYCIN A23187 HEMIMAGNESIUM SALT Property
  • storage temp. 2-8°C
  • solubility acetone: 5 mg/mL, clear, faintly yellow
  • BRN 6765085
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302+H312+H332-H315-H319-H335
  • Precautionary statements P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
CALCIMYCIN A23187 HEMIMAGNESIUM SALT Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: C9400
  • Product name : Calcium Ionophore A23187 hemimagnesium salt
  • Purity: 
  • Packaging: 5MG
  • Price: ₹35430.23
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: C9400
  • Product name : Calcium Ionophore A23187 hemimagnesium salt
  • Purity: 
  • Packaging: 10MG
  • Price: ₹61734.98
  • Updated: 2022/06/14
  • Buy: Buy

CALCIMYCIN A23187 HEMIMAGNESIUM SALT Chemical Properties,Usage,Production

  • Uses Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis[1][2][3][4].
  • in vivo

    Calcimycin (A-23187) hemimagnesium (2.5 or 7.5 nM; intrapleurally) induces protein leakage[5].

    Animal Model:Mice (ICR, 25-30 g)[5]
    Dosage:2.5 or 7.5 nM
    Administration:Intrapleurally
    Result:Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.
  • References [1] Wu Q, et al. Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin(A23187) in Streptomyces chartreusis NRRL 3882. Antimicrob Agents Chemother. 2011 Mar;55(3):974-82. DOI:10.1128/AAC.01130-10
    [2] Elliott JI, et al. IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in Tlymphocyte apoptosis. EMBO Rep. 2003 Feb;4(2):189-94. DOI:10.1038/sj.embor.embor722
    [3] Engedal N, et al. Modulation of intracellular calcium homeostasis blocks autophagosome formation. Autophagy. 2013 Oct;9(10):1475-90. DOI:10.4161/auto.25900
    [4] Mawatwal S, et al. Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner. Biochim Biophys Acta Gen Subj. 2017 Dec;1861(12):3190-3200. DOI:10.1016/j.bbagen.2017.09.010
    [5] Wang JP, et al. Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A23187-induced pleurisy and analgesia in mice. Naunyn Schmiedebergs Arch Pharmacol. 1994 Jul;350(1):90-5. DOI:10.1007/BF00180016
CALCIMYCIN A23187 HEMIMAGNESIUM SALT Preparation Products And Raw materials
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CALCIMYCIN A23187 HEMIMAGNESIUM SALT Spectrum
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