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Meclizine dihydrochloride

Meclizine dihydrochloride Structure
Meclizine dihydrochloride
  • CAS No.1104-22-9
  • Chemical Name:Meclizine dihydrochloride
  • CBNumber:CB9362486
  • Molecular Formula:C25H29Cl3N2
  • Formula Weight:463.87
  • MOL File:1104-22-9.mol
Meclizine dihydrochloride Property
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22-63
  • Safety Statements  :22-36
  • WGK Germany  :3
  • RTECS  :TL2005000
  • HS Code  :2933.59.8000
  • Toxicity :LD50 oral in mouse: 1600mg/kg
  • NFPA 704:
    0
    1 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H361
  • Precautionary statements P201-P301+P312+P330-P308+P313
Meclizine dihydrochloride Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0950
  • Product name : Meclizine dihydrochloride
  • Purity: ≥97% (HPLC)
  • Packaging: 50MG
  • Price: ₹11710.5
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: M2755
  • Product name : Meclizine Dihydrochloride
  • Purity: 
  • Packaging: 5G
  • Price: ₹7700
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: M2755
  • Product name : Meclizine Dihydrochloride
  • Purity: 
  • Packaging: 25G
  • Price: ₹9800
  • Updated: 2022/05/26
  • Buy: Buy

Meclizine dihydrochloride Chemical Properties,Usage,Production

  • Description Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM). Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung. Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.
  • Chemical Properties White or yellowish-white, slightly hygroscopic, crystalline powder.
  • Originator Antivert,Roerig,US,1957
  • Uses Meclizine Dihydrochloride is a histamine H1 receptor antagonist with antiemetic properties. Meclizine Dihydrochloride is a research product for neuroscience. This compound may exhibit neuroprotective properties.
  • Uses cholinergic, diagnostic aid
  • Uses Antiemetic;Histamine antagonist
  • Manufacturing Process 32.3 g of 1-p-chlorobenzhydryl-4-benzyl-piperazine, dissolved in 300 cm3 of alcohol are heated in an autoclave vessel, in the presence of Raney nickel, under a pressure of 100 kg H2, at about 150°C for 6 hours. The catalyst is filtered, the solvent is evaporated and the residue is fractionated under a high vacuum. p-Chlorobenzylhydryl-piperazine (BP 180° to 185°C/1 mm Hg) is isolated with a yield of 75%. Then finely ground NaNH2 is added. The mixture is heated under reflux for 1 hour, the mass is cooled and a molar equivalent of m-methyl benzyl chloride is added.
    The solvent is evaporated and the residue is dissolved in chloroform. This solution is washed with a saturated solution of K2CO3 and dried on K2CO3. The solvent is evaporated and the residue is distilled under high vacuum. The product of the condensation distills near 230°C at 2 mm Hg pressure and the corresponding dihydrochloride melts at 217° to 224°C.
  • brand name Antivert (Pfizer).
  • Therapeutic Function Antinauseant
  • Biochem/physiol Actions Meclizine has the ability to increase glycolysis and decrease cellular ATP levels in media that has glucose and galactose. It guards the kidney against ischemia-reperfusion injury. Meclizine is considered as an anti-nausea and anti-dizziness drug, was identified in a ′nutrient-sensitized′ chemical screen. In human, it acts as an agonist of pregnane X receptor (PXR). It enhances the expression of CYP3A4 (cytochrome P450 3A4) mRNA and reduces CYP3A-catalyzed testosterone 6β-hydroxylation in primary cultures of human hepatocytes.
  • Safety Profile Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cland NOx.
  • Solubility in organics Meclizine dihydrochloride is readily soluble in chloroform and pyridine, slightly soluble in dilute acids and ethanol, and insoluble in water or ether.
  • storage Desiccate at RT
Meclizine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Meclizine dihydrochloride Suppliers
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Meclizine dihydrochloride Spectrum
1104-22-9, Meclizine dihydrochlorideRelated Search:
  • PROVOCHOLINE
  • 抑制剂
  • 生化试剂
  • 药靶配体
  • 医药原料药
  • 药物杂质及中间体
  • 原料中间体-原料药
  • 原料药
  • 化工中间体
  • 化工原料
  • 其他原料
  • 医药、农药及染料中间体
  • 医药中间体
  • 氨基酸及其衍生物
  • 医药原料
  • 小分子抑制剂
  • 原料
  • 中间体
  • C25H27ClN22HCl
  • C25H29Cl3N2
  • C25H27ClN22ClH
  • C25H27Cl2N22HCl
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  • 敏克静二盐酸
  • 盐酸美克洛嗪
  • 盐酸氯苯苄嗪
  • 1-((4-氯苯基)苯甲基)-4-((3-甲苯基)甲基)哌嗪二盐酸盐
  • 1104-22-9
  • MECLIZINE HYDROCHLORIDE USP
  • Meclizine dihydrochloride, 10 mM in DMSO
  • Meclizine dihydrochloride USP/EP/BP
  • 1-(4-Chlorobenzhydryl)-4-(3-methylbenzyl)piperazine Dihydrochloride
  • )-4-(3-methyL
  • )piperazine dihydrochL
  • Meclozine dihydrochloride CRS
  • MeclizineDihydrochloride&gt
  • Meclozine ,Bonamine
  • 1-((4-Chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)p
  • Piperazine, 1-(p-chloro-a-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride (6CI, 8CI)
  • NSC 28728
  • Navidoxine
  • mecilizine hydrochloride
  • 1-(p-Chloro-a-phenylbenzyl)-4-(m-methylbenzyl)piperazine dihydrochloride
  • Meclizine diHCl
  • Meclozine dihydrochloride monohydrate
  • parachloraminedihydrochloride
  • meclozinedihydrochloride
  • Piperazine, 1-(p-chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride
  • Postafene dihydrochloride
  • Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride (9CI)

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