ChemicalBook > CAS DataBase List > CLASTO-LACTACYSTIN BETA-LACTONE
CLASTO-LACTACYSTIN BETA-LACTONE
- CAS No.154226-60-5
- Chemical Name:CLASTO-LACTACYSTIN BETA-LACTONE
- CBNumber:CB9352564
- Molecular Formula:C10H15NO4
- Formula Weight:213.23
- MOL File:154226-60-5.mol
CLASTO-LACTACYSTIN BETA-LACTONE Property
- Melting point 186-187°C
- storage temp. -20°C
- solubility DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine
- form White solid
- color White
- UNSPSC Code 12352202
- NACRES NA.77
Safety
- Hazard Codes :T
- Risk Statements :20/21/22-37/38-41-36/37/38-25
- Safety Statements :16-26-36/37/39-45
- RIDADR :UN 2811 6.1 / PGIII
- WGK Germany :2
-
NFPA 704:
3 2 0
-
Symbol(GHS)
- Signal wordWarning
- Hazard statements H319
- Precautionary statements P264-P280-P305+P351+P338-P337+P313
CLASTO-LACTACYSTIN BETA-LACTONE Price
More Price(2)
- Brand: Sigma-Aldrich(India)
- Product number: L7035
- Product name : clasto-Lactacystin β-lactone
- Purity:
- Packaging: 0.1MG
- Price: ₹43451.55
- Updated: 2022/06/14
- Buy: Buy
- Brand: Sigma-Aldrich(India)
- Product number: 426102
- Product name : clasto-Lactacystin β-Lactone - CAS 154226-60-5 - Calbiochem
- Purity: A highly specific, cell-permeable, and irreversible 20S proteasome inhibitor.
- Packaging: 100μG
- Price: ₹33440
- Updated: 2022/06/14
- Buy: Buy
CLASTO-LACTACYSTIN BETA-LACTONE Chemical Properties,Usage,Production
- Chemical Properties White Solid
- Uses clasto-Lactacystin beta-lactone is a 20S proteasome and cathepsin A inhibitor.
- Uses Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor.
- Uses A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.
- Biological Activity cell-permeable. a highly specific, potent and irreversible proteasome inhibitor. lactacystin (cat. no. 1709-200) acts as a precursor for clasto-lactacystin β-lactone and the latter compound is at least 10 times more active than the parent lactacystin
- Biochem/physiol Actions Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii?by acting in the N-threonine residue of the? β -type subunits.
CLASTO-LACTACYSTIN BETA-LACTONE Preparation Products And Raw materials
Raw materials
Preparation Products
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154226-60-5, CLASTO-LACTACYSTIN BETA-LACTONERelated Search:
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- Inhibitors
- ProteasomeInhibitors
- Proteasomes
- Protease Inhibitor Specificity Index
- P to
- Nitric Oxide and Cell Stress
- Intracellular Protein Degradation
- Proteasome inhibitorEnzyme Inhibitors by Enzyme
- Proteasome inhibitor
- InhibitorsProtease Inhibitors
- Calpain and Proteasome InhibitorsProteasome, Calpain and Lysosomal Proteases
- CLASTO-LACTACYSTIN BETA-LACTONE,20S PROTEASOME抑制剂
- 154226-60-5
- <i>clasto</i>-Lactacystin β-Lactone
- clasto-Lactacystin beta-lactone, 20S proteasome inhibitor
- 6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)-
- (1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
- Clasto-lactacystin (OMuralide)
- clasto-lactacystin β-lactone
- 1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE
- CLASTO-LACTACYSTIN BETA-LACTONE
- BETA-CLASTOLACTACYSTIN
- LACTACYSTIN, CLASTO-, BETA-LACTONE
- OMURALIDE
