Description References
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Diclofenac potassium

Description References
Diclofenac potassium Structure
Diclofenac potassium
  • CAS No.15307-81-0
  • Chemical Name:Diclofenac potassium
  • CBNumber:CB9348932
  • Molecular Formula:C14H10Cl2KNO2
  • Formula Weight:334.24
  • MOL File:15307-81-0.mol
Diclofenac potassium Property
  • Melting point 300-330 °C
  • storage temp. under inert gas (nitrogen or Argon) at 2-8°C
  • solubility Sparingly soluble in water, freely soluble in methanol, soluble in ethanol (96 per cent), slightly soluble in acetone.
  • form Solid
  • color White to off-white
  • CAS DataBase Reference 15307-81-0(CAS DataBase Reference)
  • FDA UNII L4D5UA6CB4
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
  • Hazard Codes  :Xn,N
  • Risk Statements  :22-51/53
  • Safety Statements  :61
  • RIDADR  :UN 2811 6.1 / PGIII
  • WGK Germany  :3
  • HS Code  :2922492050
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H411
  • Precautionary statements P301+P312+P330
Diclofenac potassium Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: PHR2441
  • Product name : Diclofenac potassium
  • Purity: Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging: 500MG
  • Price: ₹23760.88
  • Updated: 2022/06/14
  • Buy: Buy

Diclofenac potassium Chemical Properties,Usage,Production

  • Description Dichlofenac potassium is the potassium salt of dichlofenac. It is a nonsteroidal anti-inflammatory agent that can be used to reduce inflammation and as an analgesic to reduce pain in certain conditions. It can also used to treat dysmenorrhea. It can treat inflammatory disorders such as musculoskeletal complaints, dental pain, arthritis, actinic keratosis, joint pain, acute pain and chronic pain caused by certain kinds of cancers. Traditional opinion proposes that diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency. However, recent studies have shown that the pharmacologic activity of diclofenac goes beyond COX inhibition, and includes multimodal and, in some instances, novel mechanisms of action (MOA). For example, research suggests diclofenac can inhibit the thromboxane-prostanoid receptor, affect arachidonic acid release and uptake, inhibit lipoxygenase enzymes, and activate the nitric oxide–cGMP antinociceptive pathway. Other novel MOAs may include the inhibition of substrate P, inhibition of peroxisome proliferator activated receptor gamma (PPARγ), blockage of acid-sensing ion channels, alteration of interleukin-6 production, and inhibition of N-methyl-D-aspartate (NMDA) receptor hyperalgesia.
  • References Brogden, R. N., et al. "Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin." Drugs 20.1 (1980): 24-48.
    Gan, Tong J. "Diclofenac: an update on its mechanism of action and safety profile." Current medical research and opinion 26.7 (2010): 1715-1731.
    Riihiluoma, P., E. Wuolijoki, and M. O. Pulkkinen. "Treatment of primary dysmenorrhea with diclofenac sodium." European Journal of Obstetrics & Gynecology and Reproductive Biology 12.3 (1981): 189-194.
  • Chemical Properties White or slightly yellowish, slightly hygroscopic, crystalline powder.
  • Uses Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory.
  • Definition ChEBI: The potassium salt of diclofenac.
  • Application Diclofenac Potassium Salt is a nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor.
  • brand name Cataflam (Novartis).
Diclofenac potassium Preparation Products And Raw materials
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Diclofenac potassium Spectrum
15307-81-0, Diclofenac potassiumRelated Search:
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  • 33424
  • C14H10Cl2KNO2
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  • Diclofenac potassiumQ: What is Diclofenac potassium Q: What is the CAS Number of Diclofenac potassium Q: What is the storage condition of Diclofenac potassium

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