ChemicalBook > CAS DataBase List > 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Property

Melting point 168-170°C
Boiling point 515.3±38.0 °C(Predicted)
Density 1.03±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility Soluble in DMSO or in Ethanol.
form solid
pka 14.11±0.70(Predicted)
color White or pale yellow
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
FDA UNII 95D0I22I0V
UNSPSC Code 12352211
NACRES NA.25

Hazard and Precautionary Statements (GHS)

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Chemical Properties,Usage,Production

Description 7α-Hydroxycholesterol (566-26-7) is a metabolite resulting from the action of cholesterol 7α-hydroxylase on cholesterol. 7α-Hydroxycholesterol is the first intermediate and a rate limiting step in the major pathway for bile acid synthesis in humans.??A pro-inflammatory mediator which upregulates production of CCL2 and MMP9 in macrophages and may promote progression of atherosclerosis.2,3?Possible biomarker for cellular lipid peroxidation.4
Chemical Properties White Solid
Uses Secondary metabolite of Cholesterol.
Definition ChEBI: The 7alpha-hydroxy derivative of cholesterol.
References 1) Duane and Javitt (2002),?Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis?; J. Lab. Clin. Med.,?139?109 2) Kim?et al.?(2015)?7α-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C-C motif) ligand 2; Biochem. Biophys. Res. Commun.,?467?879 3) Kim?et al.?(2014)?27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes; Toxicol. Appl. Pharmacol.,?274?462 4) Saito and Noguchi (2014)?7-Hydroxycholesterol as a possible biomarker of cellular lipid peroxidation: difference between cellular and plasma lipid peroxidation; Biochem. Biophys. Res. Commun.,?446?741

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Preparation Products And Raw materials

Raw materials

Preparation Products

Global(86)Suppliers

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Spectrum

566-26-7, 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOLRelated Search:

Steroids
Pharmaceuticals
Metabolites & Impurities
Intermediates & Fine Chemicals
中药标准品，对照品
杂质对照品
抑制剂
生化试剂
标准品
脂类
胆甾-5-烯-3,7二醇,10 MM DMSO 溶液
7ALPHA-HYDROXYCHOLESTEROL,BILE ACID PRECURSOR
胆固醇杂质28
7Α-羟基胆固醇
7-A-羟基胆固醇未标记
7Α-羟基胆固醇(溶液)
5-胆甾烯-3-BETA,7-ALPHA-二醇
7Α-羟基胆固醇标准品
胆甾-5-烯-3
7二醇
7-ALPHA-二醇
5-胆甾烯-3-BETA
566-26-7
7α-Hydroxycholesterol, 10 mM in DMSO
7alpha-Hydroxycholesterol, Bile acid precursor
5-CHOLESTEN-3β, 7α-DIOL
peroxidation,Cholesterol,7α-Hydroxycholesterol,non-enzymatic,oxide,inhibit,biomarker,enzymatic,lipid,oxidation,Inhibitor,7α Hydroxycholesterol,7αHydroxycholesterol
(3beta,7alpha)-cholest-5-ene-3,7-diol
Cholesterol Impurity 28
Cholest-5-En-3Β,7Α-Diol
7α-Hydroxy Cholesterol
Cholest-5-ene-3,7-diol, (3β,7α)-
7α-Hydroxycholesterol (Solution)
7-alfa-Hydroxy-Cholesterol
Cholest-5-ene-3,7-diol, (3b,7a)-
Cholest-5-ene-3,7-diol, (3beta,7alpha)-
7alpha-Cholesterol
3β,7α-Dihydroxycholest-5-ene
7a-Hydroxycholest-5-en-3ol
(3,7a)-Cholest-5-ene-3,7-diol
cholest-5-en-3 beta,7 alpha-diol
5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL
7-ALPHA-HYDROXYCHOLESTEROL