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GLPG-1690

GLPG-1690 Structure
GLPG-1690
  • CAS No.1628260-79-6
  • Chemical Name:GLPG-1690
  • CBNumber:CB93152899
  • Molecular Formula:C30H33FN8O2S
  • Formula Weight:588.7
  • MOL File:1628260-79-6.mol
GLPG-1690 Property
  • Density 1.42±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO:70.84(Max Conc. mg/mL);120.32(Max Conc. mM)
    Ethanol:4.0(Max Conc. mg/mL);6.79(Max Conc. mM)
  • form A crystalline solid
  • pka 13.72±0.20(Predicted)
  • color White to off-white
  • FDA UNII I02418V13W
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

GLPG-1690 Chemical Properties,Usage,Production

  • Uses GLPG1690 is a selective autotaxin inhibitor discovered by Galapagos, with potential application in idiopathic pulmonary disease (IPF). In a Phase 1 study in healthy human volunteers, GLPG1690 demonstrated favorable safety and tolerability, as well as a strong pharmacodynamic signal implying target engagement.
  • in vivo

    Ziritaxestat (GLPG1690) inhibits ATX-induced LPA 18:2 production in mouse, rat, and healthy donor plasma in a concentration-dependent manner, with IC50 values of 418 nM, 542 nM, and 242 nM, respectively.Ziritaxestat (GLPG1690) displays improved pharmacokinetic properties, with a low plasma clearance and high bioavailability in mouse and rat. The good pharmacokinetic profile is further confirmed in dog, with Ziritaxestat (GLPG1690) showing low plasma clearance (0.12 L/h/kg) and a high bioavailability (63%)[1].

  • IC 50 Autotaxin: 131 nM (IC50); Autotaxin: 15 nM (Ki)
GLPG-1690 Preparation Products And Raw materials
Raw materials
Preparation Products
GLPG-1690 Suppliers
Global(100)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
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  • Supplier：
    TargetMol Chemicals Inc.
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  • Email：marketing@targetmol.com
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  • Supplier：
    InvivoChem
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  • Supplier：
    LEAP CHEM CO., LTD.
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  • Country：China
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  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
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GLPG-1690 Spectrum
1628260-79-6, GLPG-1690Related Search:
  • API
  • APIS
  • 化学试剂
  • 高纯试剂
  • 合成有机化合物配体
  • 抑制剂
  • C30H33FN8O2S
  • 化合物GLPG1690,10 MM DMSO 溶液
  • 2-[[2-乙基-6-[4-[2-(3-羟基-1-氮杂环丁基)-2-氧代乙基]-1-哌嗪基]-8-甲基咪唑并[1,2-A]吡啶-3-基](甲基)氨基]-4-(4-氟苯基)噻唑-5-甲腈
  • 2-[(2-乙基-6-{4- [2-(3-羟基氮杂环丁烷-1-基)-2-氧代乙基]哌嗪-1-基}-8-甲基咪唑并[1,2-A]-吡啶)(甲基)氨基]-4-(4-氟苯基)-1,3-噻唑-5-甲腈
  • 2-((2-乙基-6-(4-(2-(3-羟基氮杂环丁烷-1-基)-2-氧代乙基)哌嗪-1-基)-8-甲基咪唑并[1,2-A]吡啶-3-基)(甲基)氨基)-4-(4-氟苯基)噻唑-5-甲腈
  • GLPG1690游离态(GLPG-1690)
  • 2-[[2-乙基-6-[4-[2-(3-羟基-1-氮杂环丁烷基)-2-氧代乙基]-1-哌嗪基]-8-甲基咪唑并[1,2-A]吡啶-3-基]甲基氨基]-4-(4-氟苯基)-5-噻唑甲腈
  • 化合物GLPG1690
  • GLPG1690游离态
  • 1628260-79-6
  • Ziritaxestat, 10 mM in DMSO
  • 2-[[2-Ethyl-6-[4-[2-(3-hydroxy-1-azetidinyl)-2-oxoethyl]-1-piperazinyl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)-5-thiazolecarbonitrile
  • 2-[[2-Ethyl-6-[4-[2-(3-hydroxy-1-azetidinyl)-2-oxoethyl]-1-piperazinyl]-8-methylimidazo[1,2-a]pyridin-3-yl](methyl)amino]-4-(4-fluorophenyl)thiazole-5-carbonitrile
  • Ziritaxestat (GLPG-1690)
  • GLPG11690
  • ziritaxestat
  • 2-((2-ethyl-6-(4-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)piperazin-1-yl)-8-methylimidazo[1,2-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile
  • GLPG-1690 USP/EP/BP
  • GLPG-1690; GLPG 1690; GLPG1690; ZIRITAXESTAT.
  • GLPG 1690;GLPG1690
  • CS-2644
  • 5-Thiazolecarbonitrile, 2-[[2-ethyl-6-[4-[2-(3-hydroxy-1-azetidinyl)-2-oxoethyl]-1-piperazinyl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)-
  • GLPG-1690

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