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2,3-dihydro-2,3'-Bi-1H-indole

2,3-dihydro-2,3'-Bi-1H-indole Structure
2,3-dihydro-2,3'-Bi-1H-indole
  • CAS No.6637-10-1
  • Chemical Name:2,3-dihydro-2,3'-Bi-1H-indole
  • CBNumber:CB93145963
  • Molecular Formula:C16H14N2
  • Formula Weight:234.3
  • MOL File:6637-10-1.mol
2,3-dihydro-2,3'-Bi-1H-indole Property
  • Melting point 110-111 °C
  • Boiling point 449.3±24.0 °C(Predicted)
  • Density 1.225±0.06 g/cm3(Predicted)
  • pka 16.68±0.30(Predicted)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

2,3-dihydro-2,3'-Bi-1H-indole Chemical Properties,Usage,Production

  • Description VPC-13163 has strong anti-proliferative activity against LNCaP and Enzalutamide-resistant prostate cancer cell lines (MR49F) whereas it did not affect the growth of AR independent PC3 cell line. It also inhibits Prostate Specific Antigen (PSA) in both LNCaP and MR49F and reduces expression of AR target genes, PSA and TMPRSS2. These findings suggest that VPC-13566 exhibits AR BF3 specific mechanism of action.
  • Uses VPC13163 is a potent androgen receptor (AR) BF3 inhibitor with an IC50 of 0.31 μM. VPC13163 has anticancer effects[1].
  • References [1] Ravi Shashi Nayana Munuganti, et al. Abstract 2508: The development of anti-androgens with a novel mechanism of action for treatment of castration-resistant prostate cancer. Cancer Res (2014) 74 (19_Supplement): 2508.
2,3-dihydro-2,3'-Bi-1H-indole Preparation Products And Raw materials
Raw materials
Preparation Products
2,3-dihydro-2,3'-Bi-1H-indole Suppliers
Global(10)Suppliers
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    TargetMol Chemicals Inc.
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    TargetMol Chemicals Inc.
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  • Supplier： TargetMol Chemicals Inc.
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2,3-dihydro-2,3'-Bi-1H-indole Spectrum
  • 抑制剂
  • 化合物VPC-13163,10 MM DMSO 溶液
  • 化合物VPC-13163
  • 6637-10-1
  • VPC-13163, 10 mM in DMSO
  • 3-(Indolin-2-yl)-1H-indole
  • VPC-13163
  • VPC13163
  • VPC 13163
  • NSC52361
  • NSC 52361
  • 3'-Bi-1H-indole
  • 3-dihydro-2
  • 2,3'-Bi-1H-indole, 2,3-dihydro-
  • 2,3-dihydro-2,3'-Bi-1H-indole

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