8-ACETYL LUDACONITINE

8-ACETYL LUDACONITINE Structure
8-ACETYL LUDACONITINE
  • CAS No.127-29-7
  • Chemical Name:8-ACETYL LUDACONITINE
  • CBNumber:CB9311666
  • Molecular Formula:C36H51NO12
  • Formula Weight:689.79
  • MOL File:127-29-7.mol
8-ACETYL LUDACONITINE Property
  • Melting point 214°
  • alpha D20 +17° (alc)
  • Boiling point 697.88°C (rough estimate)
  • Density 1.2083 (rough estimate)
  • refractive index 1.6630 (estimate)
  • pka 12?+-.0.70(Predicted)
  • FDA UNII 5483BY72RT
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

8-ACETYL LUDACONITINE Chemical Properties,Usage,Production

  • Description An aconitine alkaloid obtained from A coniturn chasrnanthurn Stapf. by Dunstan and Andrews, the base crystallizes from EtOH as hexagonal prisms or rosettes of fine needles. It has [α]20Do + IS.3° (EtOH) and gives a series of crystalline salts, e.g. the hydrobromide as hexagonal prisms from H20, m.p. lS3-7°C; [edo - 17.3° or as crystals from EtOH or Et 20, m.p. 217 -SoC and the aurichloride, yellow needles, m.p. 147 -152°C with sintering at 142°C. Indaconitine resembles Aconitine (q. v.) in giving a crystalline precipitate with KMn04 but in this case the crystals are markedly smaller. Four methoxyl groups are present and when the SUlphate is heated in aqueous solution in a sealed tube it furnishes acetic acid and benzoylpseudaconine (Indbenzaconine), as a colourless glass, m.p. 130-3°C; [α]D + 33.6° (EtOH), also giving crystalline salts: hydrochloride, m.p. 242-4°C; [α]D - S.Oo (H 20); hydrobromide as the dihydrate, m.p. 247°C (dry) and the aurichloride, rosettes of orange needles, m.p. 180-2°C.
    Alkaline hydrolysis gives acetic and benzoic acids and pseudaconine, C2sH4108N. On pyrolysis, the alkaloid loses one mole of acetic acid with the formation of a-pyroindaconitine which is amorphous, m.p. 130-2°C; [α]D + 91.9° (EtOH), giving a crystalline hydro bromide, m.p. 194-SoC. When inda_x0002_conitine hydrochloride is subjected to the same treatment it yields the isomeric ~-pyroindaconitine, also amorphous, but furnishing a crystalline hydrobromide, m.p. 24S-250°C; [α]D + 27.6°.
  • Chemical Properties White crystalline, amorphous, or syrupy sub stance; salts are optically active; melts at214°C (417.2°F); insoluble in water, solublein alcohol, ether, and chloroform.
  • Uses 8-Acetyl ludaconitine occurs in the tubers of Indianaconite (bish or Aconitum ferox), found inIndia and Nepal. It is used in arrow poisoningfor hunting. Clinically, it is used in treatingrheumatism.
  • Health Hazard Feraconitine is a highly toxic alkaloid. Theacute toxic effects are similar to those ofaconitine. The symptoms from ingestionare drowsiness, nervous disorders, weakness,.
  • References Dunstan, Andrews, J. Chern. Soc., 87, 1620 (1905) See also: Bauer, Radjhan., Pharrn. Zent., 72,145 (1931)
8-ACETYL LUDACONITINE Preparation Products And Raw materials
Raw materials
Preparation Products
8-ACETYL LUDACONITINE Suppliers
Global(9)Suppliers
  • Supplier： United States Biological
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  • Supplier： Apin Chemicals Ltd.
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8-ACETYL LUDACONITINE Spectrum
  • C34H47NO10
  • C36H51NO12
  • 乙醯基藜蘆基假烏頭原鹼
  • 類烏頭鹼
  • 假烏頭鹼
  • 127-29-7
  • Aconitane-3,8,13,14-tetrol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate 14-(3,4-dimethoxybenzoate), (1α,3α,6α,14α,16β)-
  • acetylveratrylpseudoaconine
  • pseudoaconitine
  • (16S)-20-Ethyl-1α,6α,16-trimethoxy-4-methoxymethylaconitane-3α,8,13,14α-tetrol 8-acetate 14-(3,4-dimethoxybenzoate)
  • acetyl benzoylpseudo-aconine
  • 8-ACETYL LUDACONITINE
  • INDACONITINE

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