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19-Norethindrone acetate

19-Norethindrone acetate Structure
19-Norethindrone acetate
  • CAS No.51-98-9
  • Chemical Name:19-Norethindrone acetate
  • CBNumber:CB9307049
  • Molecular Formula:C22H28O3
  • Formula Weight:340.46
  • MOL File:51-98-9.mol
19-Norethindrone acetate Property
  • Melting point 161-162°
  • Boiling point 416.25°C (rough estimate)
  • Density 1.1236 (rough estimate)
  • refractive index -34 ° (C=1, Dioxane)
  • storage temp. 2-8°C
  • solubility Practically insoluble in water, freely soluble in methylene chloride, soluble in alcohol.
  • form Solid
  • color Crystals from Me2CO/hexane
  • Water Solubility 3.162mg/L(10 ºC)
  • Merck 14,6697
  • InChIKey IMONTRJLAWHYGT-ZCPXKWAGSA-N
  • CAS DataBase Reference 51-98-9(CAS DataBase Reference)
  • FDA UNII 9S44LIC7OJ
  • Proposition 65 List Norethisterone Acetate (Norethindrone Acetate)
  • NCI Drug Dictionary Aygestin
  • NIST Chemistry Reference Norethindrone acetate(51-98-9)
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :40-48
  • Safety Statements  :36/37
  • WGK Germany  :3
  • RTECS  :RC8965000
  • HS Code  :29372390
  • Toxicity :dlt-mus-orl 1120 mg/kg/4W MUREAV 26,535,74
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H351
  • Precautionary statements P201-P202-P280-P308+P313-P405-P501
19-Norethindrone acetate Price More Price(7)
  • Brand: Sigma-Aldrich(India)
  • Product number: PHR2534
  • Product name : Norethindrone acetate
  • Purity: Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging: 200MG
  • Price: ₹14473.03
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 46527
  • Product name : 19-Norethindrone acetate
  • Purity: VETRANAL?, analytical standard
  • Packaging: 100MG
  • Price: ₹8984.75
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 46527
  • Product name : 19-Norethindrone acetate
  • Purity: VETRANAL?, analytical standard
  • Packaging: 100MG
  • Price: ₹8984.75
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: N0450
  • Product name : Norethisterone Acetate
  • Purity: 
  • Packaging: 100MG
  • Price: ₹4700
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: N0450
  • Product name : Norethisterone Acetate
  • Purity: 
  • Packaging: 1G
  • Price: ₹10600
  • Updated: 2022/05/26
  • Buy: Buy

19-Norethindrone acetate Chemical Properties,Usage,Production

  • Chemical Properties White Solid
  • Originator Norlestrin,Parke Davis ,US,1964
  • Uses Oral contraceptive (in combination with estrogen)
  • Uses Progesteron. Norethindrone and acetate in combination with estrogen as contraceptive (oral). It is reasonably anticipated to be a human carcinogen.
  • Definition ChEBI: A 3-oxo Delta4-steroid that is norethisterone in which the hydroxy group has been converted to its acetate ester.
  • Manufacturing Process 2.98 grams of 17-ethinyl-19-nor-testosterone (norethindrone) are suspended in 30 cc of acetic anhydride and a solution of 1.9 grams of p-toluenesulfonic acid in 19 cc of acetic anhydride is gradually added while cooling and stirring. Complete dissolution takes place after about one hour. After additional 30 to 60 minutes, a thick, pasty mass separates. The reaction is permitted to continue for a total period of 5 hours, whereupon water is added to the reaction mixture and the 3-enol-17-diacetate which separates after stirring for 1 to 2 hours is filtered off, washed until neutral and dried in vacuo over calcium chloride at room temperature.
    In order to prepare the monoacetate, the crude diacetate is suspended in 150 cc of methanol and, after adding 1.5 cc, concentrated hydrochloric acid, heated to boiling for 15 minutes in a nitrogen atmosphere. The crude monoacetate which separates upon the addition of water after cooling is filtered off, washed and dried in vacuo over calcium chloride at room temperature. The pure 17-acetete, obtained after repeated recrystallizations from methylene chloride/hexane has a MP of 161° to 162°C.
  • brand name Aygestin (Duramed); Norlutate (Parke-Davis).
  • Therapeutic Function Chemical Name: 19-Nor-17α-pregn-4-en-20-yn-3one, 17-hydroxy-, acetate
  • General Description Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
  • Safety Profile Suspected carcinogen with experimental tumorigenic data. Human reproductive effects by ingestion and implant routes: menstrual cycle changes, postpartum effects, and changes in fertility. A human teratogen by an unspecified route with developmental abnormalities of the urogenital system. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Used in the treatment of menstrual dsorders and uterine bleedmg.
19-Norethindrone acetate Preparation Products And Raw materials
Raw materials
Preparation Products
19-Norethindrone acetate Suppliers
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19-Norethindrone acetate Spectrum
51-98-9, 19-Norethindrone acetateRelated Search:
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  • Norethindrone acetate, 10 mM in DMSO
  • 17α-Ethynyl-19-Nortestosterone 17β-Acetate
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  • C15645000 NorethisteronEacetate
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