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GSK-2126458

GSK-2126458 Structure
GSK-2126458
  • CAS No.1086062-66-9
  • Chemical Name:GSK-2126458
  • CBNumber:CB92505205
  • Molecular Formula:C25H17F2N5O3S
  • Formula Weight:505.5
  • MOL File:1086062-66-9.mol
GSK-2126458 Property
  • Melting point 187-189℃
  • Boiling point 715.6±70.0 °C(Predicted)
  • Density 1.45
  • storage temp. Refrigerator
  • solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated)
  • form Solid
  • pka 6.23±0.40(Predicted)
  • color White to Pale Yellow
  • FDA UNII 1X8F5A3NA0
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • HS Code  :29350090
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H302-H361fd-H372
  • Precautionary statements P202-P260-P264-P270-P301+P312-P308+P313
GSK-2126458 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML3161
  • Product name : GSK2126458
  • Purity: ≥98% (HPLC)
  • Packaging: 10MG
  • Price: ₹9417.75
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML3161
  • Product name : GSK2126458
  • Purity: ≥98% (HPLC)
  • Packaging: 50MG
  • Price: ₹37952.45
  • Updated: 2022/06/14
  • Buy: Buy

GSK-2126458 Chemical Properties,Usage,Production

  • Description GSK2126458 is a potent inhibitor of phosphoinositide 3-kinase isoforms (Kis = 19, 130, 24, and 60 pM for p110α, β, δ, and γ, respectively). It also inhibits mTOR in both mTORC1 and mTORC2 (Kis = 180 and 300 nM, respectively), as well as several common mutant forms of p110α. GSK2126458 is orally bioavailable, displays favorable pharmacokinetics, and shows efficacy in tumor growth models. GSK2126458 positively combines with inhibitors of discoidin domain receptor 1 (DDR1) inhibitor DDR1-IN-1 to suppress the growth of SNU-1040 colorectal cancer cells.
  • Uses A highly potent inhibitor of PI3K and the mammalian target of Rapamycin.
  • Definition ChEBI: Omipalisib is a member of the class of quinolines that is quinoline which is substituted by pyridazin-4-yl and 5-[(2,4-difluorobenzene-1-sulfonyl)amino]-6-methoxypyridin-3-yl groups at positions 4 and 6, respectively. It is a highly potent inhibitor of PI3K and mTOR developed by GlaxoSmithKline and was previously in human phase 1 clinical trials for the treatment of idiopathic pulmonary fibrosis and solid tumors. It has a role as an autophagy inducer, an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor, a mTOR inhibitor, an antineoplastic agent, a radiosensitizing agent and an anticoronaviral agent. It is a member of quinolines, a difluorobenzene, a sulfonamide, an aromatic ether, a member of pyridines and a member of pyridazines.
  • target p110α
  • storage Store at -20°C
GSK-2126458 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK-2126458 Suppliers
Global(180)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
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  • Advantage：60
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
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  • Supplier：
    Biochempartner
  • Tel：0086-13720134139
  • Email：candy@biochempartner.com
  • Country：CHINA
  • ProdList：965
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
GSK-2126458 Spectrum
1086062-66-9, GSK-2126458Related Search:
  • Sulfur & Selenium Compounds
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Heterocycles
  • Aromatics
  • PI3K/Akt/mTOR
  • Inhibitors
  • PI3K
  • mTOR
  • Akt
  • 信号转导通路激酶抑制剂
  • 医用原料
  • 抑制剂
  • 生物试剂
  • 药靶配体
  • 合成有机化合物配体
  • 细胞生物学试剂
  • 小分子抑制剂
  • 小分子抑制剂，天然产物
  • C25H17F2N5O3S
  • GSK-2126458;GSK-2126458-A;GSK-458
  • 化合物OMIPALISIB,10 MM DMSO 溶液
  • 化合物 OMIPALISIB
  • 奥米利塞
  • GSK2126458(GSK458),PI3激酶抑制剂
  • 2,4-二氟-N-[2-甲氧基-5-[4-(4-哒嗪基)-6-喹啉基]-3-吡
  • 2,4-二氟-N-(2-甲氧基-5-(4-(哒嗪-4-基)喹啉-6-基)吡啶-3-基)苯磺酰胺
  • BML-275 2HCL,COMPOUND C 2HCL
  • OMIPALISIB, 一种有效的高度选择性PI3K抑制剂
  • 2,4-二氟-N-[2-甲氧基-5-[4-(4-吡嗪)-6-喹啉]-3-吡啶]苯磺酰胺
  • PI3K抑制剂(GSK2126458)
  • 2,4-二氟-N-[2-甲氧基-5-[4-(4-哒嗪基)-6-喹啉基]-3-吡啶基]苯磺酰胺
  • 1086062-66-9
  • GSK-2126458-A
  • Omipalisib, 10 mM in DMSO
  • Omipalisib GSK2126458 GSK-2126458
  • GSK-2126458 USP/EP/BP
  • Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]-
  • Omipalisib GSK458
  • Omipalisib, 98%, a highly selective and potent inhibitor of PI3K
  • Omipalisib GSK2126458
  • CS-55
  • GSK2126458 (HYR-582)
  • GSK2126458 (GSK458);GSK458;GSK-212; GSK-2126458
  • GSK2126458(Omipalisib)
  • GSK2126458, >=98%
  • GSK2126458 (GSK458)
  • 2,4-difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide
  • GSK 2126458 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
  • 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide GSK2126458(GSK458)
  • Omipalisib (GSK2126458, GSK458)
  • GSK458
  • OMipalisib
  • 2,4-Difluoro-N-[2-Methoxy-5-[4-(pyridazin-4-yl)quinolin-6-yl]pyridin-3-yl]benzenesulfonaMide
  • GSK212
  • HYR-582
  • 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
  • GSK2126458; GSK-2126458

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