Chemical Properties
white to beige fine crystalline powder
Uses
4-Hydroxybenzophenone is used in the field of organic synthesis. It is used as pharmaceutical intermediate of clomifene citrate.
Uses
Metabolite of benzophenone.
Preparation
Preparation by condensation of benzotrichloride,
with phenol in the presence of aluminium chloride in carbon disulfide at 0° (90%) or in the presence of zinc oxide in a water bath;
with p-bromophenol in 30% sodium hydroxide solution at 80–85° (81%). There is substitution of the bromine atom by the benzoyl group.
Definition
ChEBI: 4-Hydroxybenzophenone is a member of benzophenones.
Flammability and Explosibility
Not classified
Purification Methods
Dissolve p-benzoylphenol in hot EtOH (charcoal), filter and cool. Alternatively crystallise it once from EtOH/H2O and twice from *benzene [Grunwald J Am Chem Soc 73 4934 1951, Dryland & Sheppard J Chem Soc Perkin Trans 1 125 1986]. [Beilstein 8 IV 1263.]
