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Cefmetazole

Cefmetazole Structure
Cefmetazole
  • CAS No.56796-20-4
  • Chemical Name:Cefmetazole
  • CBNumber:CB9231320
  • Molecular Formula:C15H17N7O5S3
  • Formula Weight:471.53
  • MOL File:56796-20-4.mol
Cefmetazole Property
  • Melting point 163-165?C
  • Density 1.4380 (rough estimate)
  • refractive index 1.7400 (estimate)
  • storage temp. 2-8°C
  • solubility Methanol (Slightly, Heated)
  • form Solid
  • pka 2.65±0.50(Predicted)
  • color White
  • Water Solubility Soluble in water
  • CAS DataBase Reference 56796-20-4(CAS DataBase Reference)
  • FDA UNII 3J962UJT8H
  • ATC code J01DC09
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :36/37/38-42/43
  • Safety Statements  :26-36
  • WGK Germany  :2
  • RTECS  :XI0372200
  • HS Code  :2941906000
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H317-H319-H334-H335
  • Precautionary statements P261-P280a-P284-P305+P351+P338-P405-P501a

Cefmetazole Chemical Properties,Usage,Production

  • Description Cefmetazole is a cephamycin with a nonaromatic side chain at C-7. In addition to a fairly characteristic second-generation cephalosporin antimicrobial spectrum, it possess fairly significant anti-antiaerobic activity. The ejection of its C-3 side chain leads to alcohol intolerance of the disulfuram type and prolonged clotting times.
  • General Description Cefmetazole was synthesized by Sankyo Co. in 1976starting with a biosynthetic cephamycin. It shows excellent activity against Serratia and Proteus, against which cefazolin is not active, and it has stronger activity than cefoxitin, another derivative of cephamycin. Cefmetazole is active against anaerobes and resistant to β-lactamase, but it is not active against Pseudomonas aeruginosa.
  • Chemical Properties White Solid
  • Uses A broad spectrum second generation cephalosporin antibiotic
  • Uses Semi-synthetic antibiotic derived from Cephamycin. Antibacterial.
  • Definition ChEBI: A cephalosporin antibiotic containg an N1-methyltetrazol-5-ylthiomethyl side-chain at C-3 of the parent cephem bicyclic structure.
  • Antimicrobial activity It is active against Pr. mirabilis, Pr. vulgaris, Morganella morganii, Yersinia spp.and most anaerobes. S. marcescens is moderately susceptible, but Ps. aeruginosa and E. faecalis are resistant. It is active against Mycobacterium fortuitum and some strains of M. chelonei. It is resistant to a wide range of β-lactamases.
    The serum concentration at the end of a 1 g intravenous infusion is around 77 mg/L. Plasma protein binding is 68%. It is principally excreted in the urine with a plasma half-life of c. 1.3 h; 70% is recovered over the first 6 h. In patients whose creatinine clearance is less than 10 mL/min, plasma levels are elevated and the plasma half-life is increased to around 15 h.
    Side effects associated with the methylthiotetrazole group at position C-3 have been reported. Uses are similar to those of cefoxitin, but it is not widely available.
Cefmetazole Preparation Products And Raw materials
Raw materials
Preparation Products
Cefmetazole Suppliers
Global(168)Suppliers
  • Supplier：
    Xiamen AmoyChem Co., Ltd
  • Tel：+86-86-5926051114<br/>+8615060885618
  • Email：sales@amoychem.com
  • Country：China
  • ProdList：6383
  • Advantage：58
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    SIMAGCHEM CORP
  • Tel： +86-13806087780
  • Email：sale@simagchem.com
  • Country：China
  • ProdList：17365
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
Cefmetazole Spectrum
56796-20-4, CefmetazoleRelated Search:
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  • C14H15N7O4S3
  • 化合物 CEFMETAZOLE
  • (6R,7S)-7-(2-((氰基甲基)硫基)乙酰胺基)-7-甲氧基-3 - (((1-甲基-1H-四唑-5-基)硫基)甲基)-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸
  • (6R,7S)-7-(2-((氰基甲基)硫代)乙酰胺)-7-甲氧基-3-(((1-甲基-1H-四唑-5-基)硫代)甲基)-8-氧基-5-噻-1-氮杂双环[4.2.0]辛-3-烯-2-羧酸 (头孢美唑杂质)
  • 抗生素 CS-1170
  • 头孢美唑酸/头孢美唑
  • 头孢美唑 USP标准品
  • 头孢甲氧氰唑
  • 头孢美他唑
  • 头孢美他醇
  • 头孢甲四唑
  • 先锋美他醇
  • 头孢美唑
  • (6R-cis)-7-[[[(氰甲基)硫]乙酰]氨基]-7-甲氧基-3-[[(1-甲基-1H-四唑-5-基)硫]甲基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸
  • 头袍美唑
  • 56796-20-4
  • Cefmetazole, free acid
  • (6R,7S)-7-(2-((Cyanomethyl)thio)acetamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid (Cefmetazole Impurity)
  • cs1170
  • Cefmetazolum
  • Cefmetazolo
  • Cefmetazole (1097782)
  • CEFMETAZOLE ACID 56796-20-4
  • Cefmetazole USP/EP/BP
  • (6R,7S)-7-(2-((cyanomethyl)thio)acetamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7S)-
  • Ferrous Sulfate (2 x 1 g)
  • Cefmetazole (200 mg)
  • Cefmetazole (200 mg)G0E2600.988mg/mg(ai)
  • CMZ
  • (6R,7S)-7-[[[(Cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R)-7α-[2-(Cyanomethylthio)acetylamino]-7β-methoxy-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R-cis)-7-[[[(Cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • U 72791a
  • U 72791
  • SKF 83088
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R-cis)-
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7S)-
  • Cefatrixine
  • Cefmetazole
  • CEFMETAZOLE SODIUM SALT
  • Cefmetazole, 97-103%

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