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2-Hydroxy-3-trifluoromethylpyridine

2-Hydroxy-3-trifluoromethylpyridine Structure
2-Hydroxy-3-trifluoromethylpyridine
  • CAS No.22245-83-6
  • Chemical Name:2-Hydroxy-3-trifluoromethylpyridine
  • CBNumber:CB9168839
  • Molecular Formula:C6H4F3NO
  • Formula Weight:163.1
  • MOL File:22245-83-6.mol
2-Hydroxy-3-trifluoromethylpyridine Property
  • Melting point 150-153°C
  • Boiling point 223.7±40.0 °C(Predicted)
  • Density 1.398±0.06 g/cm3(Predicted)
  • storage temp. Inert atmosphere,Room Temperature
  • form powder to crystal
  • pka 9.67±0.10(Predicted)
  • color White to Almost white
  • InChI InChI=1S/C6H4F3NO/c7-6(8,9)4-2-1-3-10-5(4)11/h1-3H,(H,10,11)
  • InChIKey JHDCDEHVUADNKQ-UHFFFAOYSA-N
  • SMILES C1(=O)NC=CC=C1C(F)(F)F
  • LogP 0.71 at 25℃
  • CAS DataBase Reference 22245-83-6(CAS DataBase Reference)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P305+P351+P338
2-Hydroxy-3-trifluoromethylpyridine Price More Price(2)
  • Brand: TCI Chemicals (India)
  • Product number: T2600
  • Product name : 3-(Trifluoromethyl)-2-pyridone
  • Purity: min. 98.0 %
  • Packaging: 1G
  • Price: ₹6900
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: T2600
  • Product name : 3-(Trifluoromethyl)-2-pyridone
  • Purity: min. 98.0 %
  • Packaging: 5G
  • Price: ₹16300
  • Updated: 2022/05/26
  • Buy: Buy

2-Hydroxy-3-trifluoromethylpyridine Chemical Properties,Usage,Production

  • Description 2-hydroxy-3-(trifluoromethyl)pyridine (or 3-(Trifluoromethyl)-2-pyridone) is a trifluoromethyl substituted 2-hydroxypyridine. It is used as a synthesis intermediate for ligands and bioactive ingredients in the application of drug discovery and catalytic reactions. In catalytic reactions, the amide group of 2-pyridone binds to transition metals, forming stable 5-/6-membered ring intermediates. Hence, 2-hydroxy-3-(trifluoromethyl)pyridine is widely used as a ligand in catalytic reactions such as directed C-H activation on meta-position. In addition, the trifluoromethyl substituent of 3-(trifluoromethyl)-2-pyridone tunes its metal-binding affinity and limits the reaction site for improving regioselectivity.
  • Chemical Properties White powder
  • Uses 2-Hydroxy-3-trifluoromethylpyridine is a reactant in the synthesis of Pyrido[2,3-b]pyrazine, a TRPV1 antagonist .
2-Hydroxy-3-trifluoromethylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Hydroxy-3-trifluoromethylpyridine Suppliers
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2-Hydroxy-3-trifluoromethylpyridine Spectrum
22245-83-6, 2-Hydroxy-3-trifluoromethylpyridineRelated Search:
  • Pyridine
  • Pyridines
  • FluoroCompounds
  • blocks
  • Fluorine series
  • 化工中间体
  • 化工原料及中间体
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  • 33252-63-1
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  • 2-羟基-3-三氟甲基吡啶, 97+%
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  • 2-羟基-3-三氟甲基吡啶 5G
  • 2-羟基-3-三氟甲基吡啶
  • 22245-83-6
  • Hydroxy-3-trifluoromethyl
  • 3-(Trifluoromethyl)-2(1H)-pyridinone
  • 2-Hydroy-3-trifluoromethylpyridine
  • 3-Trifluoromethyl-pyridin-2-ol
  • 2-HYDROXY-3-(TRIFLUOROMETHYL)PYRIDINE
  • 2-Hydroxy-3-trifluoromethylpyridine 22245-83-6
  • 2-Hydroxy-3-trifluoromethyl
  • 2-Hydroxy-3-trifluoromethylpyridine ISO 9001：2015 REACH
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  • 2-Hydroxy-3-trifluoromrthylpyridine
  • 3-Trifluoromethyl-1H-pyridin-2-one
  • 3-trifluoroMethyl-2-pyridinol
  • 2(1H)-Pyridinone, 3-(trifluoroMethyl)-
  • 3-(Trifluoromethyl)-2-pyridinone 2-Hydroxy-3-(trifluoromethyl)pyridine
  • -Hydroxy-3-trifluoroMethylpyridine
  • 2-Hydroxy-3-trifluor
  • 2-Hyddroxy-3-trifluoromethylpyridine
  • 3-(Trifluoromethyl)-2-pyridinone
  • 3-(Trifluoromethyl)pyridin-2-ol, 3-(Trifluoromethyl)pyridin-2(1H)-one
  • 2-Hydroxy-3-(trifluoromethyl)pyridine97%
  • 2-Hydroxy-3-(trifluoromethyl)pyridine 97%

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