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SKF-10047

SKF-10047 Structure
SKF-10047
  • CAS No.133005-41-1
  • Chemical Name:SKF-10047
  • CBNumber:CB9139600
  • Molecular Formula:C17H24ClNO
  • Formula Weight:293.83
  • MOL File:133005-41-1.mol
SKF-10047 Property
  • Melting point 201-203 °C
  • storage temp. room temp
  • solubility H2O: soluble
  • form solid
  • color white
  • optical activity [α]21/D +90.6°, c = 1 in ethanol(lit.)
  • Water Solubility H2O: >10mg/mL
  • FDA UNII J9S5L9NLC3
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
SKF-10047 Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: A114
  • Product name : (+)-N-Allylnormetazocine hydrochloride
  • Purity: ≥98% (HPLC)
  • Packaging: 10MG
  • Price: ₹42996.9
  • Updated: 2022/06/14
  • Buy: Buy

SKF-10047 Chemical Properties,Usage,Production

  • Uses Normetazocine analogue as opioid antagonist.
  • Biological Activity skf 10047 hydrochloride is a prototypical σ1 receptor agonist. behaviorally active in animal models of memory and stress. it has been fully demonstrated that σ binding sites are distinct from phencyclidine binding sites on the nmda receptor-ion channel complex, which has investigated extensively the functional role of σ receptors in the central nervous system [1,2].
  • Biochem/physiol Actions Selective σ1 receptor agonist.
  • in vitro the effects of the stereoisomers of n-allylnormetazocine (skf-10,047) were compared in rats on the hippocampal cholinergic functions. a putative σ1 receptor agonist, (+)-skf-10,047, increased hippocampal extracellular acetylcholine level as well as anti-amnesic effect against scopolamine-induced memory dysfunctions in rats. haloperidol, a putative σ1 receptor antagonist reversed these phenomena which were not produced by (-)-skf-10,047. such stereoselectivity and antagonism imply σ1 receptors involved in these (+)-skf-10,047-stimulated hippocampal cholinergic functions [2].
  • in vivo (+)-skf-10,047 and dextromethorphan, being co-administered with phenytoin (10 mg/kg, an anticonvulsant drug), decreased conditioned fear stress with low doses (4 and 20 mg/kg, respectively). the effects were antagonized by the σ receptor antagonists, ne-100 and bmy-14802. furthermore, the effects of (+)-skf-10,047 or dextromethorphan plus phenytoin were inhibited by the dopamine d1 receptor antagonist (sch 23390) and the dopamine d2 receptor antagonist ((-)-sulpiride), and they were also decreased by 6-hydroxydopamine-induced lesions of dopaminergic neurons. the ameliorating effects of (+)-skf-10,047 and dextromethorphan on condition of fear stress using high doses (5 and 30 mg/kg, respectively) were also inhibited by both the dopamine receptor antagonists [3].
  • storage Desiccate at +4°C
  • References [1] walker jm, bowen wd, walker fo, matsumoto rr, de costa b, rice kc. sigma receptors: biology and function. pharmacol rev. 1990 dec;42(4):355-402.
    [2] matsuno k, senda t, kobayashi t, mita s. involvement of sigma 1 receptor in (+)-n-allylnormetazocine-stimulated hippocampal cholinergic functions in rats. brain res. 1995 sep 4; 690 (2): 200-6.
    [3]. kamei h, kameyama t, nabeshima t. (+)-skf-10,047 and dextromethorphan ameliorate conditioned fear stress via dopaminergic systems linked to phenytoin-regulated sigma 1 sites. eur j pharmacol. 1996 aug 8;309(2):149-58.
SKF-10047 Preparation Products And Raw materials
Raw materials
Preparation Products
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SKF-10047 Spectrum
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Heterocycles
  • Chiral Reagents
  • 133005-41-1
  • (+)-N-Allyl Normetazocine Hydrochloride
  • (+)-SK&F 10047 hydrochloride
  • (+)-N-Allylnormetazocine
  • (2S,6S,11S)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride
  • D-NANM
  • (2S,6S,11S)-1,2,3,4,5,6-Hexahydro-6,11-diMethyl-3-(2-propen-1-yl)-2,6-Methano-3-benzazocin-8-ol Hydrochloride
  • (+)-N-Allyl-N-norMetazocine hydrochloride
  • [2S,11S,(+)]-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2β,6β-methano-3-benzazocin-8-ol
  • (2S,6S,11S)-3-Allyl-1,2,3,4,5,6-hexahydro-6,11-dimethyl-2,6-methano-3-benzazocine-8-ol
  • (+)-NANM hydrochloride, SKF-10047, [2S-(2α, 6α,11R*)]-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride
  • (+)-SKF 10047 HYDROCHLORIDE
  • SKF-10047
  • (+)-N-ALLYNORMETAZOCINE HYDROCHLORIDE
  • (+)-N-ALLYLNORMETAZOCINE HYDROCHLORIDE
  • (+)-NANM HYDROCHLORIDE
  • [2S-(2A,6A,11R*)]-1,2,3,4,5,6-HEXAHYDRO-6,11-DIMETHYL-3-(2-PROPENYL)-2,6-METHANO-3-BENZAZOCIN-8-OL HYDROCHLORIDE
  • [2S-(2ALPHA, 6ALPHA, 11R*)]-1,2,3,4,5,6-HEXAHYDRO-6,11-DIMETHYL-3(2-PROPENYL)-2,6-METHANO-3-BENZAZOCIN-8-OL HYDROCHLORIDE

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