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cirsilineol

CAS No.41365-32-6
Chemical Name:cirsilineol
CBNumber:CB91387604
Molecular Formula:C18H16O7
Formula Weight:344.32
MOL File:41365-32-6.mol

cirsilineol Property

Melting point 147 °C(Solv: benzene (71-43-2))
Boiling point 585.0±50.0 °C(Predicted)
Density 1.387
storage temp. -20°C
solubility Soluble in DMSO, ethanol and water;
pka 6.31±0.40(Predicted)
form Solid
color Yellow
Water Solubility insoluble in water
BRN 1355108
LogP 1.670 (est)
FDA UNII 08DZZ529FE
UNSPSC Code 41116107
NACRES NA.24

Safety

WGK Germany :3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Hazard statements
Precautionary statements

cirsilineol Price More Price(2)

Brand: Sigma-Aldrich
Product number: 67403
Product name : Cirsilineol
Purity: analytical standard
Packaging: 5MG
Price: ₹83947.88
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 67403
Product name : Cirsilineol
Purity: analytical standard
Packaging: 5MG
Price: ₹83947.88
Updated: 2022/06/14
Buy: Buy

cirsilineol Chemical Properties,Usage,Production

Uses Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4+ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice[1].
Definition ChEBI: A trimethoxyflavone that is flavone substituted by methoxy groups at positions 6, 7 and 3' and hydroxy groups at positions 5 and 4' respectively.

in vivo

cirsilineol (3, 10, and 30 mg/kg) significantly ameliorates TNBS-induced Th1-mediated colitis through inhibiting IFN-γ/STAT1/T-bet signaling in CD4⁺ T cells.

Animal Model:	8-10-week-old female C57BL/6, BALB/c and DO11.10 transgenic mice with TNBS (10 mg; 100 μL)^[1]
Dosage:	3, 10, 30 mg/kg
Administration:	IP; daily; for 11 days
Result:	Showed a significant improved effect on the body weights and survival rate of mice. Markedly reduced inflammatory infiltration, restoration of the destructive mucosal architecture and remission of edema.

target IFN-γ | IL Receptor | gp120/CD4 | STAT | TGF-β/Smad | JAK | PARP | Caspase | P450 (e.g. CYP17)
References [1] Yang Sun, et al. Novel immunomodulatory properties of cirsilineol through selective inhibition of IFN-gamma signaling in a murine model of inflammatory bowel disease. Biochem Pharmacol. 2010 Jan 15;79(2):229-38. DOI:10.1016/j.bcp.2009.08.014