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Methotrexate disodium salt

Methotrexate disodium salt Structure
Methotrexate disodium salt
  • CAS No.7413-34-5
  • Chemical Name:Methotrexate disodium salt
  • CBNumber:CB9136836
  • Molecular Formula:C20H23N8NaO5
  • Formula Weight:478.44
  • MOL File:7413-34-5.mol
Methotrexate disodium salt Property
  • Boiling point 823℃
  • RTECS MA1232000
  • storage temp. Keep in dark place,Inert atmosphere,2-8°C
  • solubility DMSO (Slightly), Water (Slightly)
  • form Powder
  • color Light yellow to yellow
  • Water Solubility Soluble in water
  • Sensitive Hygroscopic
  • FDA UNII 3IG1E710ZN
  • UNSPSC Code 12352200
  • NACRES NA.21
Safety
  • HazardClass  :6.1
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301
  • Precautionary statements P264-P270-P301+P310a-P321-P405-P501a

Methotrexate disodium salt Chemical Properties,Usage,Production

  • Uses Inhibits the metabolism of folic acid
  • Definition ChEBI: Methotrexate disodium is an organic sodium salt that is the disodium salt of methotrexate. It has a role as an EC 1.5.1.3 (dihydrofolate reductase) inhibitor. It contains a methotrexate(2-).
  • Biological Activity Methotrexate disodium salt is a potent is a folic acid antagonist th at is used as an antineoplastic and antirheumatic drug. Methotrexate disodium salt is a potent inhibitor of dihydrofolate reductase.
  • in vivo

    Methotrexate (Amethopterin) disodium reduces thymus and spleen indices of mice. Methotrexate disodium markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice[2].
    Methotrexate (MTX) disodium (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate disodium (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity[4].

  • IC 50 Traditional Cytotoxic Agents
Methotrexate disodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
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Methotrexate disodium salt Spectrum
7413-34-5, Methotrexate disodium saltRelated Search:
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  • C20H20N8O52Na
  • C20H20N8Na2O5
  • 甲氨蝶呤二钠盐(7413-34-5)
  • 甲氨蝶呤INT3
  • 甲氨蝶呤二钠盐(可用于细胞培养)
  • 甲氨蝶吟二钠盐
  • 甲氨蝶呤二钠盐>99
  • (S)-2-(4-(((2,4-二氨基蝶啶-6-基)甲基)(甲基)氨基)苯甲酰胺基)戊二酸二钠盐
  • 甲胺蝶吟二钠基
  • 甲氨蝶呤二钠 CAS NO. 7413-34-5
  • 加替沙星甲氨蝶呤二钠盐
  • 甲氨蝶呤二钠盐 (标准品)
  • 甲氨蝶呤二钠盐(甲氨蝶呤中间体)
  • 甲氨蝶呤二钠盐 &甲氨蝶呤 厂家
  • 甲氨蝶呤二钠
  • 甲氨喋呤二钠盐
  • 甲氨蝶呤二钠盐
  • N-[4-[[(2,4-二氨基-6-蝶啶基)甲基]甲胺基]苯甲酰基]-L-谷氨酸二钠盐
  • 7413-34-5
  • sodium (4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamate
  • N-[4-Cyano-3-(trifluoromethyl)|pheny/l-3-[(4-fluoropheny)thio)-2-hydroxy-2-methylpropionamide'
  • Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate
  • Methotrexate disodium salt USP/EP/BP
  • Methotrexatedisodiumsal
  • L-GlutaMic acid,N-[4-[[(2,4-diaMino-6-pteridinyl)Methyl]MethylaMino]benzoyl]-, sodiuM salt(1:2)
  • Methotrexate Disodium Salt Solution
  • METHOTREXATE DISODIUM SALT
  • METHOTREXATE DISODIUM
  • mtxdisodium
  • l-(+)-isodiumsal
  • disodiummethotrexate
  • amethopterinsodium
  • 4-amino-n(sup10)-methylpteroylglutamicaciddisodiumsalt
  • (+)-N-[4-[[(2,4-Diaminopteridine-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid disodium salt
  • (+)-N-[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid disodium salt
  • 2-[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]aminopentanedioic acid
  • METHOTREXATUM
  • L-Glutamic acid, N-4-(2,4-diamino-6-pteridinyl)methylmethylaminobenzoyl-, disodium salt
  • sodium methotrexate
  • Disodium N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate

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