ChemicalBook > CAS DataBase List > Scopolamine butylbromide

Scopolamine butylbromide

CAS No.149-64-4
Chemical Name:Scopolamine butylbromide
CBNumber:CB9126868
Molecular Formula:C21H30BrNO4
Formula Weight:440.37
MOL File:149-64-4.mol

Scopolamine butylbromide Property

Melting point 142-1440C
alpha D20 -20.8° (c = 3 in water)
storage temp. 2-8°C
solubility H₂O: 50 mg/mL
form powder
color white
optical activity [α]25/D 20.8°, c = 3 in H2O(lit.)
CAS DataBase Reference 149-64-4(CAS DataBase Reference)
FDA UNII 0GH9JX37C8
NCI Drug Dictionary butylscopolamine bromide
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xn
Risk Statements :22
WGK Germany :3
RTECS :YM3500000
Toxicity :LD50 in mice (mg/kg): 15.6 i.v.; 74 i.p.; 570 s.c.; 3000 orally (Stockhaus, Wick)

NFPA 704:

	0
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302+H332
Precautionary statements P261-P264-P270-P271-P301+P312-P304+P340+P312

Scopolamine butylbromide Price More Price(2)

Brand: Sigma-Aldrich(India)
Product number: S7882
Product name : (−)-Scopolamine N-butyl bromide
Purity: ≥98% (TLC), powder
Packaging: 1G
Price: ₹5553.23
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: S7882
Product name : (−)-Scopolamine N-butyl bromide
Purity: ≥98% (TLC), powder
Packaging: 5G
Price: ₹15209.13
Updated: 2022/06/14
Buy: Buy

Scopolamine butylbromide Chemical Properties,Usage,Production

Chemical Properties Crystalline Solid
Originator Butylscopolamine,China Pharm
Uses (?)-Scopolamine N-butyl bromide was used as standard in designing a procedure for quantification of compounds using CE-MS.⁸
Uses Anticholinergic. Antispasmodic
Definition ChEBI: Butylscopolamine bromide is an organic bromide salt of butylscopolamine. It is an antispasmodic drug which can relieve painful stomach cramps (including those linked with irritable bowel syndrome), bladder and menstrual cramps. It has a role as a muscarinic antagonist and an antispasmodic drug. It is an organic bromide salt and a quaternary ammonium salt. It contains a butylscopolamine.
Manufacturing Process 1300 g of scopolamine base and 350 g of n-butylbromide in 600 ml acetonitrile is heated at 65°C for 160 hours. The oil obtained is dissolved in methanol. The solution is cooled and crystalline scopolamine N-n-butylbromide is filtered. After recrystallization from methanol was obtained scopolamine N-n-butylbromide with melting point 142-144°C and [α]d 20 = -20.5° (3% solution in water); yield 65%.
Therapeutic Function Anticholinergic, Spasmolytic, Antitussive
Biochem/physiol Actions Competitive muscarinic acetylcholine receptor antagonist; antispasmodic.
Clinical Use Symptomatic relief of gastrointestinal or genitourinary disorders due to smooth muscle spasm Bowel colic
Excessive respiratory secretions
target AChR
Metabolism The main metabolic pathway is the hydrolytic cleavage of the ester bond. Orally administered hyoscine butylbromide is excreted in the faeces and in the urine. Studies in man show that 2-5% of radioactive doses is eliminated renally after oral, and 0.7-1.6% after rectal administration. Approximately 90% of recovered radioactivity can be found in the faeces after oral administration. The urinary excretion of hyoscine butylbromide is less than 0.1% of the dose. The metabolites excreted via the renal route bind poorly to muscarinic receptors and are therefore not considered to contribute to the effect of the hyoscine butylbromide.