Description
2-Bromo-1-chloro-4-fluorobenzene is an important aromatic halide that serves as a crucial intermediate in the synthesis of various organic compounds.
Uses
2-Bromo-1-chloro-4-fluorobenzene serves as the aryl electrophile in a palladium-catalyzed cascade: with benzylurea, an inorganic base and palladium precatalysts at 110 °C for 14 h it gives the corresponding 5-fluoro-substituted benzimidazolone, and with a range of ureas under the same conditions it affords 5-fluoro-1-alkylbenzimidazolones[1].
References
[1]
Ernst, J. B., Tay, N. E. S., Jui, N. T., Buchwald, S. L. (2014). Regioselective Synthesis of Benzimidazolones via Cascade C–N Coupling of Monosubstituted Ureas. Organic Letters, 16(14), 3844–3846.
https://doi.org/10.1021/ol501531q
