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Beraprost sodium

Beraprost sodium Structure
Beraprost sodium
  • CAS No.88475-69-8
  • Chemical Name:Beraprost sodium
  • CBNumber:CB8761736
  • Molecular Formula:C24H29NaO5
  • Formula Weight:420.47
  • MOL File:88475-69-8.mol
Beraprost sodium Property
  • Melting point 204-206°C
  • storage temp. -20°C
  • solubility DMF:77.0(Max Conc. mg/mL);183.12(Max Conc. mM)
    Ethanol:20.0(Max Conc. mg/mL);47.56(Max Conc. mM)
    PBS (pH 7.2):19.0(Max Conc. mg/mL);45.19(Max Conc. mM)
  • form powder
  • color white to beige
  • Water Solubility H2O: 20mg/mL, clear
  • InChIKey YTCZZXIRLARSET-LIIFYGAANA-M
  • SMILES [C@H]12[C@H](C[C@@H](O)[C@@H]1/C=C/[C@@H](O)C(C)CC#CC)OC1C(=CC=CC2=1)CCCC([O-])=O.[Na+] |&1:0,1,3,5,8,r|
  • CAS DataBase Reference 88475-69-8(CAS DataBase Reference)
  • FDA UNII 15K99VDU5F
  • UNSPSC Code 51111800
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P264-P271-P280-P302+P352-P305+P351+P338
Beraprost sodium Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1737
  • Product name : Beraprost sodium
  • Purity: ≥98% (HPLC)
  • Packaging: 1MG
  • Price: ₹13888.48
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1737
  • Product name : Beraprost sodium
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹55727.1
  • Updated: 2022/06/14
  • Buy: Buy

Beraprost sodium Chemical Properties,Usage,Production

  • Description Beraprost sodium is a new, orally active antithrombotic epoprostenol analog introduced as a treatment for peripheral vascular disease, including Raynaud's syndrome and Buerger's disease. The antiplatelet activity may be due to its elevation of cyclic AMP in platelets which is achieved by activating adenylate cyclase in the platelet membrane, followed by the inhibition ofCa++- influx and thromboxane A2 formation.
  • Description Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Doses of 20-100 μg in humans, given 1 to 3 times per day, have been demonstrated to improve clinical end points in diseases responsive to prostacyclin. Oral beraprost therapy improved the survival and pulmonary hemodynamics of patients with primary pulmonary hypertension. Beraprost inhibits platelet aggregation in healthy subjects and in diabetic patients at similar doses.
  • Chemical Properties White Solid
  • Originator Toray (Japan)
  • Uses Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).
  • Definition ChEBI: Beraprost sodium is the organic sodium salt of beraprost. It is used in the treatment of chronic arterial occlusive disease and primary pulmonary hypertension in Japan. It has a role as an antihypertensive agent, a platelet aggregation inhibitor, a prostaglandin receptor agonist, a vasodilator agent and an anti-inflammatory agent. It contains a beraprost(1-).
  • brand name Dorner; Dorner;Procylin
  • General Description Beraprost sodium is an orally active prostacyclin analog.
  • Biochem/physiol Actions Beraprost sodium is used as a therapeutic agent for chronic artery obstructions or primary pulmonary hypertension. In individuals with coronary artery disease, beraprost sodium helps to reduce oxidative stress and developed forearm endothelium dependent vasodilation.
  • Side effects Disease-related events had similar incidence in patients receiving beraprost and those receiving placebo. Drug-related adverse events like headache, flushing, jaw pain, and diarrhea were more common in patients treated with beraprost sodium and occurred mostly during the six-week titration period. The incidence was markedly reduced in the maintenance period. Six patients (9%) in the beraprost sodium group and two (3%) in the placebo group withdrew prematurely from the study because of adverse events. No clinically adverse changes in hematologic or biochemical variables were seen in the beraprost sodium group.
Beraprost sodium Preparation Products And Raw materials
Raw materials
Preparation Products
Beraprost sodium Suppliers
Global(153)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29858
  • Advantage：58
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
Beraprost sodium Spectrum
88475-69-8, Beraprost sodiumRelated Search:
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  • 前列素系列
  • 高纯试剂
  • 高纯化学试剂
  • 化学原料
  • 化学试剂-科研试剂
  • 药靶配体
  • 前列腺素系列
  • 化学试剂
  • 贝前列素杂质
  • 前列腺素类
  • C24H29NaO5
  • C24H29O5Na
  • 贝前列素钠对照品88475-69-8
  • 贝前列素钠杂质PZ02
  • 贝前列素钠杂质POZ1
  • (E)-4-(2-羟基-1-(3-羟基-4-甲基辛-1-烯-6-炔-1-基)-2,3,3A,8B-四氢-1H-环戊二钠[ B]苯并呋喃-5-基)丁酸酯 (贝列前素杂质)
  • 贝前列素钠盐
  • 贝前列素-13C-D3 钠盐
  • 贝拉普罗斯特钠盐
  • 贝拉前列素13C-D3钠盐
  • 2,3,3A-8B-四氢-2-羟基-1-(3-羟基-4-甲基-1-辛烯-6-炔基)-1H-环戊并[B]苯并呋喃-5-丁酸钠
  • 贝前列素钠88475-69-8,工厂零售88475-69-8
  • 贝前列素钠
  • 88475-69-8
  • Beraprost-13C-d3 Sodium Salt (Mixture of Diastereomers)
  • (Rac)-Beraprost (sodium)
  • Beraprost sodium impurity
  • sodium,4-[2-hydroxy-1-[(E)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate
  • Sodium 4-(2-hydroxy-1-(3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl)butanoate
  • Sodium (E)-4-(2-hydroxy-1-(3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl)butanoate (Beraprost Impurity)
  • BERAPROST SODIUM SALT
  • Beraprost sodium USP/EP/BP
  • sodium 4-[2-hydroxy-1-[(E)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl]butanoate
  • Beprostaglandin sodium
  • 2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-yn-1-yl)-1H-cyclopenta[b]benzofuran-5-butanoic acid sodium salt
  • Procyclin
  • Beraprost sodium###Beraprost
  • Unii-15K99vdu5f
  • Befraprost
  • Sodium 2,3,3a-8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta[b]benzofuran-5-butanoate
  • Careload
  • Berasus
  • dl-4-[(1R,2R,3aS,8bS)-2,3,3a,8b-Tetrahydro-2-hydroxy-[(3S,4RS)-3-hydroxy-4-Methyl-oct-6-yne-(E)-1-enyl]-5-cyclopenta[b]benzofuranyl]butanoic Acid SodiuM
  • MDL 201129
  • Dorner
  • 1H-Cyclopenta[b]benzofuran-5-butanoic acid, 2,3,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-, monosodium salt
  • 2,3,3A-8B-TETRAHYDRO-2-HYDROXY-1-(3-HYDROXY-4-METHYL-1-OCTEN-6-YNYL)-1H-CYCLOPENTA[B]BENZOFURAN-5-BUTANOIC ACID, SODIUM SALT
  • TRK 100
  • PROCYLIN
  • ML 1129
  • beraprostsodium

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