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LY3143921

LY3143921 Structure
LY3143921
  • CAS No.1627696-53-0
  • Chemical Name:LY3143921
  • CBNumber:CB85867383
  • Molecular Formula:C16H14FN5O2
  • Formula Weight:327.32
  • MOL File:1627696-53-0.mol
LY3143921 Property
  • storage temp. Store at -20°C
  • solubility DMSO: 65 mg/mL (198.59 mM);Ethanol: 32 mg/mL (97.77 mM)
  • form Solid
  • color White to off-white
  • Water Solubility Water: Insoluble
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

LY3143921 Chemical Properties,Usage,Production

  • Uses LY3177833 (Example 4) monhydrate is an orally active CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively. LY3177833 monhydrate is a senescence inducer[1][2].
  • Biological Activity LY3143921 hydrate is an orally administered ATP-competitive CDC7 inhibitor.
  • in vivo

    LY3177833 (Example 4; 10.4-31.2 mg/kg; oral gavage; twice a day; for 2 weeks; female athymic Balb/c nude mice with SW620 cells) treatment causes significant tumor regression in a dose-dependent manner. Also, no significant tumor growth is observed for 2 weeks after dosing cessation[1].

    Animal Model:Female athymic Balb/c nude mice (5-6 weeks old) with SW620 cells[1]
    Dosage:10.4 mg/kg, 20.8 mg/kg and 31.2 mg/kg
    Administration:Oral gavage; twice a day for 2 weeks
    Result:Showed dose dependent antitumor activity in SW620 mouse xenograft tumor model.
  • IC 50 Cdc7: 3.3 nM (IC50); pMCM2: 290 nM (IC50)
  • References [1] Peter F. Gallagher, et al. Journal of Clinical Oncology. Volume 37, Issue 15_suppl.
LY3143921 Preparation Products And Raw materials
Raw materials
Preparation Products
LY3143921 Suppliers
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LY3143921 Spectrum
1627696-53-0, LY3143921Related Search:
  • 抑制剂
  • LY-3143921;LY-3143921 HYDRATE
  • LY3177833 MONHYDRATE
  • 化合物LY3143921 HYDRATE
  • 1627696-53-0
  • LY-3143921 hydrate,LY3143921 hydrate
  • LY3143921 hydrate
  • LY3143921

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