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giredestrant

giredestrant Structure
giredestrant
  • CAS No.1953133-47-5
  • Chemical Name:giredestrant
  • CBNumber:CB85839636
  • Molecular Formula:C27H31F5N4O
  • Formula Weight:522.55
  • MOL File:1953133-47-5.mol
giredestrant Property
  • Boiling point 618.8±55.0 °C(Predicted)
  • Density 1.333±0.06 g/cm3(Predicted)
  • pka 13.68±0.10(Predicted)
  • form Solid
  • color Light yellow to yellow
  • FDA UNII 28P3DU6DB3
  • NCI Drug Dictionary giredestrant
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

giredestrant Chemical Properties,Usage,Production

  • Uses Giredestrant (GDC-9545), a non-steroidal estrogen receptor (ER) ligand, is an orally active and selective ER antagonist. Giredestrant potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity[1].
  • IC 50 ER
  • References [1] C Metcalfe, et al. Abstract P5-04-07: GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes
giredestrant Preparation Products And Raw materials
Raw materials
Preparation Products
giredestrant Suppliers
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    Aladdin Scientific
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giredestrant Spectrum
1953133-47-5, giredestrantRelated Search:
  • api
  • 化学试剂
  • 抑制剂
  • C27H31F5N4O
  • 化合物GIREDESTRANT,10 MM DMSO 溶液
  • 3-((1R,3R)-1-(2,6-二氟-4-((1-(3-氟丙基)氮杂环丁烷-3-基)氨基)苯基)-3-甲基-1,3,4,9-四氢-2H-吡啶并[3,4-B]吲哚-2-基)-2,2-二氟丙烷-1-醇
  • 吉雷司群
  • 化合物GIREDESTRANT
  • GDC-9545 ; GDC9545 ; GDC 9545 ; RG6171 ; RG-6171 ; RG 6171 ; GIREDESTRANT ;
  • 1953133-47-5
  • Giredestrant, 10 mM in DMSO
  • 3-((1R,3R)-1-(2,6-Difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol
  • ligand,conformational,GDC 9545,inhibit,non-steroidal,anti-tumor,GDC9545,Inhibitor,Giredestrant,orally,Estrogen Receptor/ERR,change
  • Giredestrant(GDC-9545）
  • Giredestrant,GDC-0945
  • RG-6171
  • RG6171
  • RG 6171
  • GDC-9545(Giredestrant)
  • 2H-Pyrido[3,4-b]indole-2-propanol, 1-[2,6-difluoro-4-[[1-(3-fluoropropyl)-3-azetidinyl]amino]phenyl]-β,β-difluoro-1,3,4,9-tetrahydro-3-methyl-, (1R,3R)-
  • GDC-9545
  • giredestrant

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