Description References
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Tizanidine hydrochloride

Description References
Tizanidine hydrochloride Structure
Tizanidine hydrochloride
  • CAS No.64461-82-1
  • Chemical Name:Tizanidine hydrochloride
  • CBNumber:CB8480703
  • Molecular Formula:C9H9Cl2N5S
  • Formula Weight:290.17
  • MOL File:64461-82-1.mol
Tizanidine hydrochloride Property
  • Melting point 280 °C
  • Flash point 9℃
  • storage temp. Inert atmosphere,Room Temperature
  • solubility H2O: ~29 mg/mL
  • form solid
  • color white
  • Water Solubility H2O: >20mg/mL
  • Merck 14,9485
  • InChI InChI=1S/C9H8ClN5S.ClH/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9;/h1-2H,3-4H2,(H2,11,12,13);1H
  • InChIKey ZWUKMNZJRDGCTQ-UHFFFAOYSA-N
  • SMILES N1=C2C=CC(Cl)=C(NC3NCCN=3)C2=NS1.[H]Cl
  • CAS DataBase Reference 64461-82-1(CAS DataBase Reference)
  • EWG's Food Scores 1
  • FDA UNII B53E3NMY5C
  • NCI Drug Dictionary tizanidine hydrochloride
  • UNSPSC Code 41116107
  • NACRES NA.77
Safety
  • Hazard Codes  :Xn,Xi
  • Risk Statements  :22-36/37/38
  • Safety Statements  :26-36-37/39
  • RIDADR  :UN1230 - class 3 - PG 2 - Methanol, solution
  • WGK Germany  :3
  • RTECS  :DK9910000
  • HS Code  :2934990002
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Tizanidine hydrochloride Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: T6950
  • Product name : Tizanidine hydrochloride
  • Purity: ≥98% (HPLC), powder
  • Packaging: 10MG
  • Price: ₹10045.6
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: T6950
  • Product name : Tizanidine hydrochloride
  • Purity: ≥98% (HPLC), powder
  • Packaging: 50MG
  • Price: ₹45107.78
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: T2527
  • Product name : Tizanidine Hydrochloride
  • Purity: 
  • Packaging: 5G
  • Price: ₹5500
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: T2527
  • Product name : Tizanidine Hydrochloride
  • Purity: 
  • Packaging: 25G
  • Price: ₹9100
  • Updated: 2022/05/26
  • Buy: Buy

Tizanidine hydrochloride Chemical Properties,Usage,Production

  • Description As an adrenergic agonist with muscle relaxant activity, tizanidine hydrochloride belongs to the hydrochloride salt form of tizanidine, which is commonly used in the treatment of spasticity, a condition where muscles in human body spasm, cramp, or become tight induced by a variety of medical problems such as multiple sclerosis, spinal cord injury, Lou Gehrig's disease, spastic diplegia, back pain or certain other injuries to the spine or central nervous system. Besides, as a sleep aid and an anticonvulsant, tizanidine hydrochloride has off-label usage for migraine headaches and is effective for some symptoms of fibromyalgia.
    As a short-acting muscle relaxer, the antinociceptive effect of tizanidine hydrochloride functions by blocking excess nerve impulses (pain sensations) of the nerve cells that are sent to the brain and control muscle movement, ultimately resulting in muscle relaxation and spasticity alleviation.
  • References https://en.wikipedia.org/wiki/Tizanidine
    http://www.webmd.com/drugs/2/drug-1024/tizanidine-oral/details
    http://bodyandhealth.canada.com/drug/getdrug/pal-tizanidine
    https://pubchem.ncbi.nlm.nih.gov/compound/114869#section=Top
    https://www.drugs.com/tizanidine.html
  • Chemical Properties Off-White to pale Yellow Solid
  • Originator Nimzox,Rapross Pharmaceuticals Pvt. Ltd.,India
  • Uses Anticoagulant
  • Uses Tizanidine (Zanaflex) is a drug that is used as a muscle relaxant. It is a centrally acting α-2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, spastic diplegia,
  • Uses An α2-adrenergic agonist; centrally active myotonolytic. A muscle relaxant (skeletal).
  • Definition ChEBI: Tizanidine hydrochloride is a benzothiadiazole.
  • Manufacturing Process 14 ml of benzoyl chloride are added to a solution of 11.5 g of ammonium thiocyanate in 150 ml of acetone in an ice bath and the mixture is then stirred for 10 min. This solution is heated to the boil at reflux together with 19 g of 4-amino-5-chloro-2,1,3-benzothiadiazole. The solution is cooled to room temperature and diluted with a 4-fold quantity of water. The precipitate is filtered off and rapidly brought to a boil together with 150 ml of a 2 N aqueous sodium hydroxide solution and kept at the boil for 5 min. The solution is cooled to room temperature, is acidified weakly with glacial acetic acid, the precipitate is filtered off, washed with ether and recrystallized from methanol. The N-(5-chloro-2,1,3-benzothiadiazol-4-yl)thiourea, obtained and this is boiled for 1 h together with 9 g of methyl iodide in 150 ml of methanol. After concentrating by evaporation, crude S-methyl-N-(5-chloro-2,1,3- benzothiadiazol-4-yl)isothiuronium iodide is obtained. 9.8 g of S-methyl-N-(5- chloro-2,1,3-benzothiadiazol-4-yl)isothiuronium iodide are heated to the boil at reflux for 1 h together with 50 ml of methanol and 1.8 ml of ethylene diamine. The solvent is then removed by evaporation and the moist residue is boiled at reflux for 1 h together with 20 ml of n-amyl alcohol. The mixture is subsequently shaken with 50 ml of chloroform and 150 ml of water until all the material is dissolved. 40 ml of a 2 N aqueous sodium hydroxide solution are added to the aqueous phase and extraction is effected with 200 ml of chloroform. The organic phase is dried and concentrated by evaporation. After recrystallizing the residue from methanol with the addition of some active charcoal, 4-(2-imidazolin-2-yl-amino)-5-chloro-2,1,3-benzothiadiazole, having a melting point of 221-223°C, is obtained. The 4-(2-imidazolin-2-yl-amino)-5-chloro-2,1,3-benzothiadiazole hydrochloride may be obtained by the teaction of 4-(2-imidazolin-2-yl-amino)-5-chloro- 2,1,3-benzothiadiazole with hydrochloric acid.
  • brand name Tizanidine is INN and BAN.
  • Therapeutic Function Muscle relaxant, Spasmolytic
  • Biological Activity α 2 -adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC 50 = 48 nM). Also binds to imidazoline receptor.
  • storage Desiccate at RT
Tizanidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Tizanidine hydrochloride Suppliers
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  • Supplier：
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Tizanidine hydrochloride Spectrum
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