3-Chloro-4-fluorobenzotrifluoride

Chemical Properties

Uses

Synthesis

328-84-7

78068-85-6

In a 500 mL four-neck flask equipped with a condenser, 200 mL of N,N-dimethylacetamide (DMA), 0.2 mol of 3,4-dichlorobenzotrifluoride, 1.0 mol of potassium fluoride, and 0.01 mol of tetraphenylphosphine chloride were added. The reaction mixture was heated to 150°C until the gas chromatography (GC) content of the feedstock 3,4-dichlorobenzotrifluoride was less than 1%. Upon completion of the reaction, potassium fluoride and catalyst were recovered by diafiltration for use in the next batch of the reaction. The mother liquor was dissolved and purified by distillation to give 3-chloro-4-fluorobenzotrifluoride in 99% purity and 90% yield.

References