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1,1-Diethoxybutane

1,1-Diethoxybutane Structure
1,1-Diethoxybutane
  • CAS No.3658-95-5
  • Chemical Name:1,1-Diethoxybutane
  • CBNumber:CB8388533
  • Molecular Formula:C8H18O2
  • Formula Weight:146.23
  • MOL File:3658-95-5.mol
1,1-Diethoxybutane Property
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :10-36/38
  • Safety Statements  :26-37/39-16
  • RIDADR  :UN 1993C 3 / PGIII
  • WGK Germany  :3
  • HS Code  :29329990
  • NFPA 704:
    3
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H226-H315-H319
  • Precautionary statements P305+P351+P338

1,1-Diethoxybutane Chemical Properties,Usage,Production

  • Chemical Properties Clear colorless liquid
  • Uses 1,1-Diethoxybutane-d10 is a deuterated labeled 1,1-Diethoxybutane[1].
  • Preparation To a three-necked flask equipped with an air-tight mechanical stirrer, dropping funnel, reflux condenser, and drying tube, are added 3.0 gm (1.25 gm-atom) magnesium turnings, 50 ml of dry ether, and a small crystal of iodine. Then 5 gm of rt-butyl bromide is added dropwise until 171.0 gm (1.25 mole) has been added. The reaction takes about ½ - l h r if the reaction mixture is cooled. The solution is refluxed for ½ hr, cooled to 50°C, and then 148 gm (1.0 mole) of triethyl orthoformate is added dropwise over a ½-hr period. The reaction mixture is refluxed for 16 hr, crushed ice added to decompose the excess Grignard reagent, the ether separated and washed with water. The water layer is added to a separatory funnel containing 200 ml of ether, treated with acetic acid to pH 7.0, shaken, and the ether separated. The latter ether layer is washed with 10% aqueous sodium carbonate, water, and dried. The latter water layer is extracted twice again with ether (200 ml). The combined ether layers are dried over potassium carbonate and fractionated to afford 128 gm (80%), b.p. 143°-144°.
    Preparation of n-Butyraldehyde Diethyl Acetal
  • References [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
1,1-Diethoxybutane Preparation Products And Raw materials
Raw materials
Preparation Products
1,1-Diethoxybutane Suppliers
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1,1-Diethoxybutane Spectrum
3658-95-5, 1,1-DiethoxybutaneRelated Search:
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  • 3658-95-5
  • Butane, 1,1-diethoxy-
  • 1,1-DIETHOXYBUTANE
  • Butanal diethyl acetal
  • BUTYRALDEHYDE DIETHYLACETAL, 97+%
  • butyraldehyde ethyl acetal
  • BUTRALDEHYDE DIETHYL ACETAL
  • BUTYRALDEHYDE DIETHYL ACETAL
  • n-Butyraldehyde diethyl acetal
  • Butylaldehyde diethyl acetal

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