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LEU-ENKEPHALIN AMIDE

LEU-ENKEPHALIN AMIDE Structure
LEU-ENKEPHALIN AMIDE
  • CAS No.60117-24-0
  • Chemical Name:LEU-ENKEPHALIN AMIDE
  • CBNumber:CB8373676
  • Molecular Formula:C28H38N6O6
  • Formula Weight:554.64
  • MOL File:60117-24-0.mol
LEU-ENKEPHALIN AMIDE Property
  • Melting point 123-126 °C
  • Boiling point 1012.8±65.0 °C(Predicted)
  • Density 1.254±0.06 g/cm3(Predicted)
  • storage temp. −20°C
  • solubility Soluble in DMSO
  • form Solid
  • pka 9.97±0.15(Predicted)
  • color White to off-white
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

LEU-ENKEPHALIN AMIDE Chemical Properties,Usage,Production

  • Uses [Leu5]-Enkephalin, amide is a δ opioid receptor agonist.
  • in vivo

    Levels of [Leu5]-Enkephalin are significantly increased in the nucleus raphe magnus (NRM) of rats 2 weeks after the injection of complete Freund's adjuvant (CFA) (1.02±0.2 pmol/mg protein) as compared with saline-treated rats (0.49±0.04 pmol/mg protein; p<0.01). Tissue levels of [Leu5]-Enkephalin are uniformly increased in the caudal ventrolateral periaqueductal gray (PAG) 4 hr (1.15±0.25 pmol/mg protein), 4 d (1.16±0.18 pmol/mg protein), and 2 weeks (1.18±0.17 pmol/mg protein) after the injection of CFA as compared with saline-treated rats (0.55±0.03 pmol/mg protein; p<0.05, all times). A smaller increase in the levels of [Leu5]-Enkephalin occurred in the rostral aspect of the ventrolateral PAG at all time points. Finally, levels of [Leu5]-Enkephalin are also increased in the contralateral microcellular tegmental nucleus 4 d after the injection of CFA (0.53±0.04 pmol/mg protein) compared with levels in saline-treated rats (0.38±0.02 pmol/mg protein; p<0.05)[1].

  • References [1] Hurley RW, et al. Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury. J Neurosci. 2001 Apr 1;21(7):2536-45. DOI:10.1523/JNEUROSCI.21-07-02536.2001
    [2] Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8. DOI:10.1111/j.1476-5381.1987.tb11323.x
LEU-ENKEPHALIN AMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
LEU-ENKEPHALIN AMIDE Suppliers
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LEU-ENKEPHALIN AMIDE Spectrum
60117-24-0, LEU-ENKEPHALIN AMIDERelated Search:
  • Opioid Peptides
  • Peptides
  • Enkephalins
  • BioChemical
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • C28H38N6O6
  • 亮氨酸-脑啡肽酰胺
  • 受体激动剂多肽LEU-ENKEPHALIN, AMIDE
  • 2-[[2-[[2-[[2-[[2-AMINO-3-(4-HYDROXYPHENYL)PROPANOYL]AMINO]ACETYL]AMINO]ACETYL]AMINO]-3-PHENYLPROPANOYL]AMINO]-4-METHYLPENTANAMIDE
  • 60117-24-0
  • Leu-Enkephalin amide acetate salt H-Tyr-Gly-Gly-Phe-Leu-NH2 acetate salt
  • NSC 351912
  • L-Leucinamide, L-tyrosylglycylglycyl-L-phenylalanyl-
  • Leu-Enkephalin amide acetate salt
  • Leu-Enkephalin amide,α-Neoendorphin (1-5) amide
  • a-Neoendorphin (1-5) aMide, Dynorphin A (1-5) aMide
  • L-Tyr-Gly-Gly-L-Phe-L-Leu-NH2
  • 4-Hydroxy-L-Phe-Gly-Gly-Phe-Leu-NH2
  • leucine enkephalinamide
  • TYR-GLY-GLY-PHE-LEU-NH2
  • YGGFL-NH2
  • enkephalinamide-leu
  • [LEU5]-ENKEPHALIN AMIDE
  • LEU-ENKEPHALIN AMIDE
  • LEU-ENKEPHALIN NH2
  • H-TYR-GLY-GLY-PHE-LEU-NH2 ACETATE SALT
  • H-TYR-GLY-GLY-PHE-LEU-NH2
  • DYNORPHIN A (1-5) AMIDE ACETATE SALT
  • DYNORPHIN A (1-5) AMIDE
  • leucine enkephalinamide acetate
  • ALPHA-NEOENDORPHIN (1-5) AMIDE

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