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1,2,4-Benzenetriol

CAS No.533-73-3
Chemical Name:1,2,4-Benzenetriol
CBNumber:CB8356419
Molecular Formula:C6H6O3
Formula Weight:126.11
MOL File:533-73-3.mol

1,2,4-Benzenetriol Property

Melting point 140 °C (subl.) (lit.)
Boiling point 194.21°C (rough estimate)
Density 1.45 g/cm3 (20℃)
refractive index 1.5627 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Sparingly), Methanol (Slightly)
form Solid
pka 9.58±0.10(Predicted)
color Plates from Et2O
Water Solubility freely soluble
Sensitive Air Sensitive
Merck 14,1073
BRN 2042863
Stability Light Sensitive, Moisture Sensitive
CAS DataBase Reference 533-73-3(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 173O8B04RD
NIST Chemistry Reference 1,2,4-Benzenetriol(533-73-3)
EPA Substance Registry System 1,2,4-Benzenetriol (533-73-3)
UNSPSC Code 12352104
NACRES NA.23

Safety

Hazard Codes :Xn,Xi
Risk Statements :22-37/38-41-36/37/38-20/21/22
Safety Statements :26-39-36/37/39-22
WGK Germany :3
RTECS :DC4200000
Hazard Note :Irritant/Keep Cold/Air Sensitive
TSCA :Yes
HS Code :2907 29 00
Toxicity :oms-hmn:lym 50 mmol/L CNREA8 45,2471,85

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H302-H315-H318-H335
Precautionary statements P280-P301+P312+P330-P302+P352-P305+P351+P338+P310

1,2,4-Benzenetriol Price More Price(9)

Brand: Sigma-Aldrich(India)
Product number: 8.43791
Product name : 1,2,4-Trihydroxybenzene
Purity: for synthesis
Packaging: 5G
Price: ₹8750
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 8.43791
Product name : 1,2,4-Trihydroxybenzene
Purity: for synthesis
Packaging: 25G
Price: ₹29220
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 173401
Product name : 1,2,4-Benzenetriol
Purity: ReagentPlus?, 99%
Packaging: 1G
Price: ₹2035.1
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 173401
Product name : 1,2,4-Benzenetriol
Purity: ReagentPlus?, 99%
Packaging: 5G
Price: ₹7555.85
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: H0249
Product name : 1,2,4-Trihydroxybenzene
Purity: min. 98.0 %
Packaging: 10G
Price: ₹7800
Updated: 2022/05/26
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1,2,4-Benzenetriol Chemical Properties,Usage,Production

Chemical Properties Gray powder
Physical properties 1,2,4-Benzenetriol forms colorless platelets or prisms that quickly colorize in air. It is soluble in water and polar solvents, and slightly soluble in chloroform and carbon disulfide.
Uses 1,2,4-Trihydroxybenzene is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.It is used as a metabolite of benzene.
Definition ChEBI: Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite.
Production Methods 1,2,4-Benzenetriol is synthesized by hydrolysis of 1,2,4-triacetoxybenzene, which is prepared by the acid-catalyzed reaction of p-benzoquinone with acetic anhydride.
Other production methods for 1,2,4-Benzenetriol are oxidation of resorcinol with hydrogen peroxide and Dakin oxidation of 2,4- or 3,4-dihydroxybenzaldehydes or 2,4- or 3,4-dihydroxyacetophenones with alkaline hydrogen peroxide solution.
General Description 1,2,4-Benzenetriol is also known as hydroxyhydroquinone. It is an intermediary metabolite of benzene that is present in roasted coffee beans. It is mutagenic and it causes cleaving of DNA single strands by the generation of reactive oxygen species.
Chemical Reactivity 1,2,4-Benzenetriol is, like other phenols, a strong reducing agent. Its basic aqueous solution absorbs gaseous oxygen to produce black precipitates of the humic acid type. 1,2,4-Benzenetriol shows typical reactions of phenols. Derivatives of the tautomeric keto form are also known: halogenation of hydroxyhydroquinone, for example, gives 1,2,5,5-tetrahalocyclohexene-3,4,6-trione. Condensation with ethylacetoacetate produces dihydroxycoumarin; reaction with phthalic anhydride yields hydroxyhydroquinonephthalein. Monosubstitution of a hydroxy group by an amino group occurs easily at room temperature and gives 2,4-dihydroxyaniline.
Safety Profile Poison by subcutaneous and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification Methods Crystallise the triol from Et2O or Et2O/EtOH, and dry it in a vacuum. The picrate forms orange-red needles m 96o. [Beilstein 6 H 1087, 6 I 541, 6 II 1071, 6 III 6276.]