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E3 Ligase Ligand-Linker Conjugates 19

E3 Ligase Ligand-Linker Conjugates 19 Structure
E3 Ligase Ligand-Linker Conjugates 19
  • CAS No.1799711-24-2
  • Chemical Name:E3 Ligase Ligand-Linker Conjugates 19
  • CBNumber:CB83386468
  • Molecular Formula:C19H22N4O6
  • Formula Weight:402.4
  • MOL File:1799711-24-2.mol
E3 Ligase Ligand-Linker Conjugates 19 Property
  • Boiling point 757.5±60.0 °C(Predicted)
  • Density 1.397±0.06 g/cm3(Predicted)
  • solubility DMF: insol; DMSO: insol; Ethanol: insol; PBS (pH 7.2): 3 mg/ml
  • form A solid
  • pka 10.68±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

E3 Ligase Ligand-Linker Conjugates 19 Chemical Properties,Usage,Production

  • Description Thalidomide-O-acetamido-C4-amine HCl salt is comprised of a Thalidomide based cereblon ligand and a ligand-linker conjugate. This E3 ligase ligand-linker conjugate is used in PROTAC technology.
  • Uses Thalidomide-O-amido-C4-NH2 (Cereblon Ligand-Linker Conjugates 6), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
  • IC 50 Cereblon
  • References [1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression.J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816
    [2] James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.
E3 Ligase Ligand-Linker Conjugates 19 Preparation Products And Raw materials
Raw materials
Preparation Products
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E3 Ligase Ligand-Linker Conjugates 19 Spectrum
1799711-24-2, E3 Ligase Ligand-Linker Conjugates 19Related Search:
  • 抑制剂
  • 杂质对照品
  • 化合物 THALIDOMIDE-O-AMIDO-C4-NH2
  • E3 LIGASE LIGAND-LINKER CONJUGATES 19|||CEREBLON LIGAND-LINKER CONJUGATES 6
  • N-(4-氨基丁基)-2-[[2-(2,6-二氧代-3-哌啶基)-1,3-二氧代异吲哚啉-4-基]氧基]乙酰胺
  • N-(4-氨基丁基)-2-((2-(2,6-二氧代哌啶-3-基)-1,3-二氧代异吲哚啉-4-基)氧基)乙酰胺
  • N-(4-氨基丁基)-2-((2-(2,6-二氧代哌啶-3-基)-1,3-二氧异吲哚啉-4-基)氧基)乙酰胺
  • 萨力多胺-O-酰胺-C4-氨基
  • 1799711-24-2
  • Pomadomide impurity 27
  • N-(4-aminobutyl)-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide
  • N-(4-Aminobutyl)-2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]oxy]acetamide
  • E3 Ligand-Linker Conjugate 3(E3 Ligase Ligand-Linker Conjugates 19)
  • N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
  • Acetamide, N-(4-aminobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
  • Thalidomide-O-amido-C4-NH2
  • Cereblon Ligand-Linker Conjugates 6
  • E3 Ligand-Linker Conjugate 3
  • E3 Ligase Ligand-Linker Conjugates 19

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