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Biotin-PEG4-Methyltetrazine

Biotin-PEG4-Methyltetrazine Structure
Biotin-PEG4-Methyltetrazine
  • CAS No.1835759-81-3
  • Chemical Name:Biotin-PEG4-Methyltetrazine
  • CBNumber:CB83344947
  • Molecular Formula:C27H39N7O6S
  • Formula Weight:589.71
  • MOL File:1835759-81-3.mol
Biotin-PEG4-Methyltetrazine Property
  • Density 1.233±0.06 g/cm3(Predicted)
  • solubility Soluble in DMSO, DMF
  • pka 13.90±0.40(Predicted)
  • form Solid
  • color Purple to purplish red
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Biotin-PEG4-Methyltetrazine Chemical Properties,Usage,Production

  • Description Biotin-PEG4-methyltetrazine is a click chemistry biotinylation reagent that can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity.
  • Uses Biotin-PEG4-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG4-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
  • IC 50 PEGs
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Biotin-PEG4-Methyltetrazine Preparation Products And Raw materials
Raw materials
Preparation Products
Biotin-PEG4-Methyltetrazine Suppliers
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Biotin-PEG4-Methyltetrazine Spectrum
1835759-81-3, Biotin-PEG4-MethyltetrazineRelated Search:
  • 抑制剂
  • C27H39N7O6S
  • 化合物 BIOTIN-PEG4-METHYLTETRAZINE
  • N-(2-(2-(2-(2-(4-(6-甲基)-1,2,4,5-四嗪-3-基)苯氧基)乙氧基)乙氧基)乙氧基)乙基)-5-((3AR,4R,6AS)-2-氧代六氢-1H-噻吩并[3,4-D]咪唑-4-基)戊酰胺
  • 生物素-四聚乙二醇-甲基四嗪
  • 生物素-PEG4-甲基四嗪
  • 1835759-81-3
  • N-(2-(2-(2-(2-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
  • 1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-N-[2-[2-[2-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-2-oxo-, (3aR,4R,6aS)-rel-
  • Biotin-PEG4-Methyltetrazine

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