ChemicalBook > CAS DataBase List > Tulobuterol
Tulobuterol
- CAS No.41570-61-0
- Chemical Name:Tulobuterol
- CBNumber:CB8320201
- Molecular Formula:C12H18ClNO
- Formula Weight:227.73
- MOL File:41570-61-0.mol
Tulobuterol Property
- Melting point 89-91°C
- Boiling point 338.2±27.0 °C(Predicted)
- Density 1.098±0.06 g/cm3(Predicted)
- RTECS DA4734170
- storage temp. -20°C Freezer
- solubility DMSO (Slightly), Methanol (Slightly)
- pka 13.62±0.20(Predicted)
- form Solid
- color White to Off-White
- CAS DataBase Reference 41570-61-0(CAS DataBase Reference)
- FDA UNII 591I9SU0F7
- ATC code R03AC11,R03CC11
- UNSPSC Code 12352200
Safety
- Safety Statements :24/25
- HS Code :29214990
- Toxicity :LD50 in male mice, rats, rabbits (mg/kg): 305, 850, 563 orally; 170, 417, 164 s.c. (Kubo, 1975)
-
Symbol(GHS)
- Signal wordWarning
- Hazard statements H302
- Precautionary statements P264-P270-P301+P312a-P330-P501a
Tulobuterol Chemical Properties,Usage,Production
- Chemical Properties Crystalline Solid
- Uses A sympathomimetic drug used as a transdermal patch, increases normal diaphragm muscle strength. A β-adrenergic receptor agonist, related structurally to Terbutaline (T109750).
- Uses A ?adrenergic receptor agonist, related structurally to Terbutaline
- Uses Tulobuterol is a sympathomimetic drug used as a transdermal patch, increases normal diaphragm muscle strength.
- Definition ChEBI: 2-(tert-butylamino)-1-(2-chlorophenyl)ethanol is an organochlorine compound.
-
in vivo
In vivo effect of Tulobuterol is examined the on the contractility of diaphragm muscles prepared from mice (BALBs/c mice; 21.7 ± 0.2 g) treated with Endotoxin. Contractile parameters of force-frequency curves and twitch kinetics using untreated or treated diaphragm muscles at 0 (E0) and 4 (E4) hours after E. coli endotoxin (20 mg/kg) administration are measured. E0 and E4 diaphragm muscles are analyzed at 0, 12, and 24 h after transdermal Tulobuterol treatment. The force-frequency curves of E0 and E4 diaphragm muscles at three time points are not significantly changed each other, indicating that Tulobuterol patch restores the muscle contractility. Thus, diaphragm muscle contractility is maintained during 4 h of endotoxin administration with Tulobuterol patch for over 24 h[2].
- IC 50 β adrenergic receptor
Tulobuterol Preparation Products And Raw materials
Raw materials
Preparation Products
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- Tulobutero
- TULOBUTEROL BASE
- 1-(2-chlorophenyl)-2-[[1,1,1,3,3,3-hexadeuterio-2-(trideuteriomethyl)propan-2-yl]amino]ethanol
- Tulobuterol USP/EP/BP
- Benzenemethanol, 2-chloro-α-[[(1,1-dimethylethyl)amino]methyl]-
- Tulobuterol, racemic mixture
- Tulobuterol（mixture of isomers）
- 2-(tert-ButylaMino)-1-(2-chlorophenyl)ethanol
- Tulobuterol API
- o-Chloro-α-[(tert-butylaMino)Methyl]benzyl Alcohol
- 2-Chloro-α-[[(1,1-diMethylethyl)aMino]Methyl]benzeneMethanol
- α-[(tert-Butylamino)methyl]-2-chlorobenzenemethanol
- Tulobuten
- Tulobunist
- Sekinarin
- 2-(tert-Butylamino)-1-(o-chlorophenyl)ethanol
- 2-Chloro-a-[[(1,1-dimethylethyl)amino]methyl]benzenemethanol
- Tulobuterol (base and/or unspecified salts)
- Tulobuterol Bane
- o-Chloro-a-[(tert-butylamino)methyl]benzyl alcohol
- HN 078
- Benzenemethanol, 2-chloro-a-[[(1,1-dimethylethyl)amino]methyl]- (9CI)
- 2-Chloro-a-[[(1,1-dimethylethyl)amino]methyl]benzenemethano
- alpha-[(tert-butylamino)methyl]-o-chlorobenzyl alcohol
- Tulobuterol(baseandorunspecifiedsalt)
- TulobuterolHcl56776-01-3/Base
- TULOBUTEROL
