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t-Boc-N-amido-PEG8-acid

t-Boc-N-amido-PEG8-acid Structure
t-Boc-N-amido-PEG8-acid
  • CAS No.1334169-93-5
  • Chemical Name:t-Boc-N-amido-PEG8-acid
  • CBNumber:CB83062669
  • Molecular Formula:C24H47NO12
  • Formula Weight:541.63
  • MOL File:1334169-93-5.mol
t-Boc-N-amido-PEG8-acid Property
  • Boiling point 627.6±55.0 °C(Predicted)
  • Density 1.122±0.06 g/cm3(Predicted)
  • solubility Soluble in Water, DMSO, DCM, DMF
  • pka 4.28±0.10(Predicted)
  • form Liquid
  • color Colorless to light yellow
Safety
  • HS Code  :2942000090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P280-P301+P312-P302+P352-P305+P351+P338

t-Boc-N-amido-PEG8-acid Chemical Properties,Usage,Production

  • Description t-Boc-N-amido-PEG8-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
  • Uses Boc-NH-PEG8-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • IC 50 PEGs; Alkyl/ether
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
t-Boc-N-amido-PEG8-acid Preparation Products And Raw materials
Raw materials
Preparation Products
t-Boc-N-amido-PEG8-acid Suppliers
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t-Boc-N-amido-PEG8-acid Spectrum
1334169-93-5, t-Boc-N-amido-PEG8-acidRelated Search:
  • peg
  • 抑制剂
  • PEG系列产品-Boc-PEG系列
  • 助剂
  • C24H47NO12
  • T-BOC-N-氨基-PEG8-酸
  • N-BOC-八聚乙二醇-羧酸
  • BOC-NH-PEG8-酸
  • 叔丁氧羰基-PEG8-羧酸
  • 2,2-二甲基-4-氧代-3,8,11,14,17,20,23,26,29-九氧杂-5-氮杂三十二烷-32-酸
  • 氨基叔丁酯-八聚乙二醇-羧酸
  • 氨基叔丁酯-九聚乙二醇-羧酸
  • T-BOC-N-AMIDO-PEG8-COOH,BOC-N-AMIDO-PEG8-ACID
  • 叔丁氧羰基八聚乙二醇丙酸
  • N-叔丁氧羰基-八聚乙二醇-羧酸
  • N-叔丁氧羰基-七聚乙二醇-羧酸
  • 1334169-93-5
  • alpha-tert-Butyloxycarbonylamino-omega-carboxy octa(ethylene glycol)
  • t-boc-N-amido-dPEG??-acid (QBD-10760)
  • 3-[2-[2-[2-[2-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
  • 1-(tert-Butyl) 5,8,11,14,17,20,23,26-octaoxa-2-azanonacosanedioate
  • BocNH-PEG8-CH2CH2COOH/5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid, 1-(1,1-dimethylethyl) ester
  • Boc NH PEG8 CH2CH2COOH,inhibit,Inhibitor,PROTAC Linkers,Boc-NH-PEG-8-CH2CH2COOH,BocNHPEG8CH2CH2COOH
  • 1-(1,1-Dimethylethyl) 5,8,11,14,17,20,23,26-octaoxa-2-azanonacosanedioate
  • BocNH-PEG8-C2-COOH
  • 2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23,26,29-nonaoxa-5-azadotriacontan-32-oic acid
  • Boc-NH-PEG8-acid
  • t-Boc-N-amido-PEG8-COOH,Boc-N-amido-PEG8-acid
  • 5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid, 1-(1,1-dimethylethyl) ester
  • T-BOC-NH-AMIDO-PEG8-COOH
  • Boc-N-amido-PEG8-acid
  • t-Boc-N-amido-PEG9-acid
  • t-Boc-N-amido-PEG8-acid

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