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DBCO-PEG5-NHS ester

DBCO-PEG5-NHS ester Structure
DBCO-PEG5-NHS ester
  • CAS No.1378531-80-6
  • Chemical Name:DBCO-PEG5-NHS ester
  • CBNumber:CB83062467
  • Molecular Formula:C36H43N3O11
  • Formula Weight:693.74
  • MOL File:1378531-80-6.mol
DBCO-PEG5-NHS ester Property
  • Density 1.32±0.1 g/cm3(Predicted)
  • storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
  • solubility Acetonitrile (Slightly), Chloroform (Slightly)
  • form Oil
  • pka 15.14±0.46(Predicted)
  • color Yellow to Dark Yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

DBCO-PEG5-NHS ester Chemical Properties,Usage,Production

  • Description DBCO-NHCO-PEG5-NHS ester is a PEG linker containing NHS ester that is able to react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and can also provide a long and flexible connection that minimizes steric hindrance during ligation. DBCO is commonly used for copper-free Click Chemistry reactions.
  • Uses DBCO-NHCO-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-NHCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
  • IC 50 PEGs
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
DBCO-PEG5-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
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DBCO-PEG5-NHS ester Spectrum
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