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HG-14-10-04

HG-14-10-04 Structure
HG-14-10-04
  • CAS No.1356962-34-9
  • Chemical Name:HG-14-10-04
  • CBNumber:CB82715638
  • Molecular Formula:C29H34ClN7O
  • Formula Weight:532.08
  • MOL File:1356962-34-9.mol
HG-14-10-04 Property
  • Boiling point 761.1±70.0 °C(Predicted)
  • Density 1.297±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO : 13.3 mg/mL (25.00 mM; Need ultrasonic and warming)
  • form Powder
  • pka 14.62±0.30(Predicted)
  • color Light yellow to yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

HG-14-10-04 Chemical Properties,Usage,Production

  • Uses HG-14-10-04 is a potent ALK and mutant EGFR inhibitor with IC50s of 20 nM, 15.6 nM, 22.6 nM and 124.5 nM for ALK, EGFRLR/TM, EGFR19del/TM/CS and EGFRLR/TM/CS, respectively. HG-14-10-04 can be used to research anticancer[1][2].
  • Definition ChEBI: 5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2-pyrimidinamine is a member of piperidines.
  • IC 50 EGFRLR/TM: 15.6 nM (IC50); EGFR19del/TM/CS: 22.6 nM (IC50); EGFRLR/TM/CS: 124.5 nM (IC50); ALK: 20 nM (IC50)
  • References [1] U.S. Pat. Appl. Publ. (2012), US 20120028924 A1
    [2] Chen H, et al. Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J Med Chem. 2022 May 12;65(9):6840-6858. DOI:10.1021/acs.jmedchem.2c00168
HG-14-10-04 Preparation Products And Raw materials
Raw materials
Preparation Products
HG-14-10-04 Suppliers
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    TargetMol Chemicals Inc.
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HG-14-10-04 Spectrum
1356962-34-9, HG-14-10-04Related Search:
  • 抑制剂
  • 药靶配体
  • 化合物HG-14-10-04,10 MM DMSO 溶液
  • 5-氯-4-(1H-吲哚-3-基)-N-(2-甲氧基-4-(4-(4-甲基哌嗪-1-基)哌啶-1-基)苯基)嘧啶-2-胺
  • 化合物HG-14-10-04
  • 1356962-34-9
  • HG-14-10-04, 10 mM in DMSO
  • Anaplastic lymphoma kinase (ALK),HG 14 10 04,Anaplastic lymphoma kinase,ErbB-1,Inhibitor,EGFR,anticancer,HG141004,CD246,inhibit,HER1,Cluster of differentiation 246,Epidermal growth factor receptor,ALK tyrosine kinase receptor
  • 2-Pyrimidinamine, 5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-
  • CS-1175
  • CS-2526
  • 5-chloro-4-(1H-indol-3-yl)-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-2-amine
  • HG-14-10-04

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