1H-Indole-2-carboxylic acid, 4-Methyl-, ethyl ester

Synthesis

24512-97-8

16732-80-2

The general procedure for the synthesis of ethyl 4-methyl-1hydro-indole-2-carboxylate from the compound (CAS: 24512-97-8) was as follows: 19.5 g (0.0844 mol) of the azide prepared in step 1 was added in batches to 100 mL of xylene preheated to 140 °C. After the addition was completed, the reaction mixture was kept at 140 °C for 1 hour. At the end of the reaction, the xylene was removed by concentration via reduced pressure distillation, and the residue was dissolved in isopropyl ether, filtered, and dried under vacuum at 40 °C for 18 h to give a white crystalline product. The melting point of the product was 141 °C and the yield was 62%.

References