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Isonicotinamide

Isonicotinamide Structure
Isonicotinamide
  • CAS No.1453-82-3
  • Chemical Name:Isonicotinamide
  • CBNumber:CB8259608
  • Molecular Formula:C6H6N2O
  • Formula Weight:122.12
  • MOL File:1453-82-3.mol
Isonicotinamide Property
  • Melting point 155-157 °C(lit.)
  • Boiling point 227.52°C (rough estimate)
  • Density 1.2236 (rough estimate)
  • refractive index 1.5350 (estimate)
  • storage temp. Store below +30°C.
  • solubility DMSO (Slightly), Methanol (Slightly)
  • form Solid
  • pka pK1: 3.61(+1) (20°C)
  • color White to Off-White
  • Water Solubility 191.7 g/L (37 ºC)
  • BRN 2173
  • LogP -0.28
  • CAS DataBase Reference 1453-82-3(CAS DataBase Reference)
  • EWG's Food Scores 1
  • FDA UNII 4H3BH6YX9Q
  • NIST Chemistry Reference 4-Pyridinecarboxamide(1453-82-3)
  • EPA Substance Registry System Isonicotinamide (1453-82-3)
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :26-36
  • WGK Germany  :3
  • RTECS  :NR9500000
  • Hazard Note  :Irritant
  • TSCA  :Yes
  • HS Code  :29333999
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H335-H315-H319
  • Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Isonicotinamide Price More Price(8)
  • Brand: Sigma-Aldrich(India)
  • Product number: I17451
  • Product name : Isonicotinamide
  • Purity: ReagentPlus?, 99%
  • Packaging: 25G
  • Price: ₹2890.28
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: I17451
  • Product name : Isonicotinamide
  • Purity: ReagentPlus?, 99%
  • Packaging: 100G
  • Price: ₹3983.6
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: ALFA India
  • Product number: ALF-A18190-36
  • Product name : Isonicotinamide, 99%
  • Purity: 
  • Packaging: 500g
  • Price: ₹11389
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: ALFA India
  • Product number: ALF-A18190-30
  • Product name : Isonicotinamide, 99%
  • Purity: 
  • Packaging: 250g
  • Price: ₹9636
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: I0135
  • Product name : Isonicotinamide
  • Purity: 
  • Packaging: 25G
  • Price: ₹2400
  • Updated: 2022/05/26
  • Buy: Buy

Isonicotinamide Chemical Properties,Usage,Production

  • Chemical Properties white crystalline powder
  • Uses Isonicotinamide is an isomeric analogue of nicotinamide and a metabolite of isonicotinic thioamide. Isonicotinamide strongly inducde apoptosis in human acute myelomonocytic leukemia cells, HL-60.
  • Application Isonicotinamide (pyridine-4-carboxamide) can be used as a heterocyclic building block to synthesize:
    4-oxo-1,3-thiazinan-3-yl isonicotinamide derivatives as potential anti-tubercular agents.
    Organotin(IV) complexes of isonicotinamide via synthesis of phosphoramidate ligands for various biological activity studies.
    Bis-pyridinium isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as potent reactivators sarin.
    Isonicotinamide can also be used as a co-former with active pharmaceutical ingredients (APIs) to prepare co-crystals.
  • Preparation synthesis of isonicotinamide: In 6g tert-amyl alcohol, add 100mg ferric oxide, 100mg cobalt tetroxide and 100mg manganese dioxide (mass percentage in the mixture: 4.6%), 60mg 4-cyanopyridine (mass percentage in the mixture: 0.91%), 200uL Water (mass percentage in the mixture: 3.0%), mix well; react at 80°C for 24 hours, the conversion rate of 4-cyanopyridine is 99.0%, and the selectivity of the corresponding Isonicotinamide is 99.0%.
  • Definition ChEBI: Isonicotinamide is a pyridinecarboxamide that is the monocarboxylic acid amide derivative of isonicotinic acid. It derives from an isonicotinic acid.
  • Purification Methods Recrystallise isonicotinamide from hot water or isopropanol (158.5-159o), and dry it in a vacuum at 100o. The picrate crystallises from aqueous EtOH or H2O and has m 217-218o (214-215o). [Beilstein 22 III/IV 527, 22/2 V 195.]
Isonicotinamide Preparation Products And Raw materials
Raw materials
Preparation Products
Isonicotinamide Suppliers
Global(473)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
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  • ProdList：21628
  • Advantage：55
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  • Country：China
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  • Advantage：58
  • Supplier：
    Xiamen AmoyChem Co., Ltd
  • Tel：+86-86-5926051114<br/>+8615060885618
  • Email：sales@amoychem.com
  • Country：China
  • ProdList：6383
  • Advantage：58
Isonicotinamide Spectrum
1453-82-3, IsonicotinamideRelated Search:
  • Pyridine
  • Apoptosis, Aromatics, Heteocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
  • 酶制剂
  • 抑制剂
  • 原料药
  • 高端化学
  • 系列1
  • 有机化工
  • 杂质对照品
  • 原料药及中间体
  • 食品添加剂
  • 有机化工原料
  • 医药、农药及染料中间体
  • 添加剂1
  • 添加剂
  • 化工中间体
  • 原料
  • 小分子抑制剂
  • 医药原料
  • 吡啶
  • 通用试剂
  • 医药中间体
  • 杂环砌块
  • C6
  • Building Blocks
  • Pyridines
  • Heterocyclic Building Blocks
  • 1453-83-0
  • 异烟碱/AR
  • 烟酰胺杂质4(烟酰胺EP杂质D)
  • 尼克酰胺EP杂质D(异烟酰胺、异烟肼EP杂质B)
  • 烟酰胺杂质D
  • 异烟肼EP杂质B
  • 烟酰胺EP杂质D
  • 异烟酰胺 标准品
  • 异烟酰胺对照品
  • 烟酰胺杂质4
  • 异烟肼杂质3
  • 吡啶-4-甲酰胺
  • 异烟碱,99%
  • 4-吡啶甲酰胺 100G
  • 异烟酰胺,99%
  • 异烟酰胺 B135168不存在
  • 4-吡啶甲酰胺(99%)
  • 异烟酰胺,4-吡啶甲酰胺
  • 异烟胺
  • 異咸胺
  • 4-吡啶甲酰胺(异烟酰胺)
  • 异烟酸酰胺
  • 吡啶甲酰胺
  • 氨甲酰基吡啶
  • 异烟酰胺
  • 4-甲酰氨基吡啶
  • 4-吡啶甲酰胺
  • 1453-82-3
  • Nicotinamide Impurity D
  • Nicotinamide EP Impurity D (Isonicotinamide、Isoniazid EP Impurity B)
  • Isopyridin-3-carboxamide

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