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4-(Pyridin-3-yl)pyrimidin-2-amine

4-(Pyridin-3-yl)pyrimidin-2-amine Structure
4-(Pyridin-3-yl)pyrimidin-2-amine
  • CAS No.66521-66-2
  • Chemical Name:4-(Pyridin-3-yl)pyrimidin-2-amine
  • CBNumber:CB8228031
  • Molecular Formula:C9H8N4
  • Formula Weight:172.19
  • MOL File:66521-66-2.mol
4-(Pyridin-3-yl)pyrimidin-2-amine Property
  • Melting point 189-191 °C
  • Boiling point 439.9±37.0 °C(Predicted)
  • Density 1.259±0.06 g/cm3(Predicted)
  • storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
  • solubility DMSO (Slightly), Methanol (Slightly)
  • form Solid
  • pka 2.76±0.10(Predicted)
  • color Off-White to Pale Yellow
  • InChI InChI=1S/C9H8N4/c10-9-12-5-3-8(13-9)7-2-1-4-11-6-7/h1-6H,(H2,10,12,13)
  • InChIKey LQHQKYWYKPLKCH-UHFFFAOYSA-N
  • SMILES C1(N)=NC=CC(C2=CC=CN=C2)=N1
  • UNSPSC Code 12352116
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319
  • Precautionary statements P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
4-(Pyridin-3-yl)pyrimidin-2-amine Price More Price(2)
  • Brand: TCI Chemicals (India)
  • Product number: P2666
  • Product name : 4-(Pyridin-3-yl)pyrimidin-2-amine
  • Purity: min. 98.0 %
  • Packaging: 1G
  • Price: ₹4200
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: P2666
  • Product name : 4-(Pyridin-3-yl)pyrimidin-2-amine
  • Purity: min. 98.0 %
  • Packaging: 5G
  • Price: ₹19400
  • Updated: 2022/05/26
  • Buy: Buy

4-(Pyridin-3-yl)pyrimidin-2-amine Chemical Properties,Usage,Production

  • Chemical Properties White to off-white or brown solid.
  • Uses 4-(3-Pyridinyl)-2-pyrimidinamine serves as an intermediate compound during the synthesis of Nilotinib. Nilotinib is a selective tyrosine kinase receptor inhibitor used in the therapy of chronic myelogenous leukemia.
  • Synthesis 3-(Dimethylamino)-1-(pyridine-3-yl) prop-2-en-1-one (15.4 g, 0.088 mol), guanidine nitrate (10.7 g, 0.088 mol), and sodium hydroxide (3.5 g, 0.088 mol) were dissolved in n-butanol (120 mL). The mixture was heated to reflux with stirring and maintained for 16 hours. The reaction mixture was then cooled to room temperature. The solid was collected and washed with water (400 mL). The desired product was dried under vacuum for three days, and 12.7 g of yellow crystals of 4-(Pyridin-3-yl)pyrimidin-2-amine was obtained (yield: 85 %).
4-(Pyridin-3-yl)pyrimidin-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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4-(Pyridin-3-yl)pyrimidin-2-amine Spectrum
66521-66-2, 4-(Pyridin-3-yl)pyrimidin-2-amineRelated Search:
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  • 中间体定制类
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  • 尼罗替尼中间体
  • C9H8N4
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  • 2-氨基-4-(3-吡啶基)嘧啶
  • 4-(3-吡啶基)-2-氨基嘧啶
  • 4-(3-吡啶基)-2-嘧啶胺
  • 4 - (吡啶- 3 -基)嘧啶-2-胺
  • 66521-66-2
  • 4-(PYRIDIN-3-YL)PYRIMIDIN-2-AMINE
  • 4-(3-Pyridinyl)-2-aminopyrimidineQ: What is 4-(3-Pyridinyl)-2-aminopyrimidine Q: What is the CAS Number of 4-(3-Pyridinyl)-2-aminopyrimidine Q: What is the storage condition of 4-(3-Pyridinyl)-2-aminopyrimidine Q: What are the applications of 4-(3-Pyridinyl)-2-aminopyrimidine
  • 4-(3-Pyridinyl)-2-aminopyrimidine ISO 9001：2015 REACH
  • Nilotinib 3-Pyridinyl Impurity
  • )-2-pyrimidine amine
  • 4-(3-Pyridinyl)-2-pyrimidine amine, 97%, reagent grade
  • 4-(3-piridinyl)-2-pirimidine amine
  • 2-Amino-4-(3-pyridyl)pyrimidine
  • 2-PyriMidinaMine,4-(3-pyridinyl)-
  • 4-Pyridin-3-yl-pyriMidin-2-ylaMine
  • 2-amino-4-(3-pyridinyl)-pyrimidine
  • 4-(3-Pyridinyl)-2-pyrimidine amine ,97%
  • 4-(3-Pyridyl)-2-pyrimidineamine
  • 4-(3-Pyridinyl)-2-aminopyrimidine
  • 4-(3-Pyridyl)-2-pyrimidinamine
  • 4-(3-PYRIDINYL)-2-PYRIMIDINYLAMINE
  • 4-(3-PYRIDINYL)-2-PYRIMIDINE AMINE
  • 4-(3-PYRIDINYL)-2-PYRIMIDINAMINE
  • BUTTPARK 41\09-83

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