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α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6

α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6 Structure
α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6
  • CAS No.1173021-86-7
  • Chemical Name:α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6
  • CBNumber:CB82092289
  • Molecular Formula:C5D6O5
  • Formula Weight:152.135110668
  • MOL File:1173021-86-7.mol
α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6 Property
  • Melting point 114-117 °C
  • form Solid
  • color White to off-white
  • UNSPSC Code 12352115
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :37/38-41
  • Safety Statements  :26-39
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H315-H318-H335
  • Precautionary statements P280-P305+P351+P338-P310-P264-P280-P302+P352-P321-P332+P313-P362

α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6 Chemical Properties,Usage,Production

  • Uses 2-Ketoglutaric acid-d6 is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].
  • References [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
    [2] Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35. DOI:10.1128/MMBR.00038-15
    [3] Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec105(Pt 3):1654-1662. DOI:10.1016/j.ijbiomac.2016.12.015
α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6 Preparation Products And Raw materials
Raw materials
Preparation Products
α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6 Suppliers
Global(11)Suppliers
  • Supplier： LGC Science (Shanghai) Ltd.
  • Tel： 17717235263
  • Email：cindy.yang@lgcgroup.com
  • Country：China
  • ProdList：17730
  • Advantage：58
  • Supplier： Merck KGaA
  • Tel：21-20338288
  • Email：ordercn@merckgroup.com
  • Country：China
  • ProdList：292394
  • Advantage：58
α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6 Spectrum
  • C5D6O5
  • DO2CCD2CD2COCO2D
  • Α-KETOGLUTARIC ACID-D6, Α-KETOPENTANOIC ACID-D6
  • A-酮丁酸(D6,98%)
  • 1173021-86-7
  • 2-Ketoglutaric acid-d<sub>6</sub>
  • 2-Oxo-1,5-pentanedioic Acid-d6
  • EOS-60378
  • ALPHA-KETOGLUTARIC ACID (D6, 98%)
  • 2-oxopentanedioic-3,3,4,4-d4acid-d2
  • α-Ketopentanoic acid-d6
  • α-Ketoglutaric acid-d6
  • 2-Ketoglutaric acid-d6
  • α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6
  • 2-Ketopentanedioic acid-d6

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