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Atorvastatin

Atorvastatin Structure
Atorvastatin
  • CAS No.110862-48-1
  • Chemical Name:Atorvastatin
  • CBNumber:CB81269853
  • Molecular Formula:C33H35FN2O5
  • Formula Weight:558.64
  • MOL File:110862-48-1.mol
Atorvastatin Property
  • Boiling point 722.2±60.0 °C(Predicted)
  • Density 1.23±0.1 g/cm3(Predicted)
  • pka 4.29±0.10(Predicted)
  • FDA UNII 36TN91XZ0V
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Atorvastatin Chemical Properties,Usage,Production

  • Definition ChEBI: Atorvastatin is a dihydroxy monocarboxylic acid that is a member of the drug class known as statins, used primarily for lowering blood cholesterol and for preventing cardiovascular diseases. It has a role as an environmental contaminant and a xenobiotic. It is an aromatic amide, a member of monofluorobenzenes, a statin (synthetic), a dihydroxy monocarboxylic acid and a member of pyrroles. It is functionally related to a heptanoic acid. It is a conjugate acid of an atorvastatin(1-).
  • Clinical Use Hyperlipidaemia and hypercholesterolaemia
  • Drug interactions Potentially hazardous interactions with other drugs Anti-arrhythmics: concentration possibly increased by dronedarone. Antibacterials: azithromycin, erythromycin, clarithromycin or fusidic acid possibly increased risk of myopathy - avoid atorvastatin for at least 7 days after fusidic acid stopped; concentration increased by clarithromycin - do not exceed 20 mg of atorvastatin1 ; avoid with telithromycin; increased risk of myopathy with daptomycin; concentration possibly reduced by rifampicin.
    Anticoagulants: may transiently reduce anticoagulant effect of warfarin.
    Antifungals: increased risk of myopathy with itraconazole - do not exceed 40 mg of atorvastatin1 ;
    increased risk of myopathy with fluconazole, ketoconazole, posaconazole, voriconazole and possibly other imidazoles and triazoles - avoid.
    Antivirals: increased risk of myopathy with atazanavir, boceprevir (reduce atorvastatin dose), and possibly darunavir, fosamprenavir, indinavir, lopinavir, ritonavir, saquinavir or tipranavir (max dose of atorvastatin 10 mg); concentration reduced by efavirenz and possibly etravirine; avoid with dasabuvir, ombitasvir, paritaprevir and telaprevir; possible increased risk of myopathy with ledipasvir - reduce atorvastatin dose; concentration increased by simeprevir - consider reducing atorvastatin dose.
    Calcium channel blockers: concentration increased by diltiazem - increased risk of myopathy; concentration of verapamil increased also possible increased risk of myopathy - consider reducing atorvastatin dose.
    Ciclosporin: increased risk of myopathy - do not exceed 10 mg of atorvastatin.1 Cobicistat: reduce atorvastatin dose.
    Colchicine: possible increased risk of myopathy.
    Grapefruit juice: concentration possibly increased.
    Lipid lowering agents: increased risk of myopathy
    with fibrates, gemfibrozil (avoid) and nicotinic acid.
  • Metabolism Atorvastatin undergoes extensive presystemic clearance in gastrointestinal mucosa and/or hepatic first-pass metabolism. Atorvastatin is metabolised by cytochrome P450 3A4 to ortho- and parahydroxylated derivatives and various beta-oxidation products. These products are further metabolised via glucuronidation. Approximately 70% of circulating inhibitory activity for HMG-CoA reductase is attributed to active metabolites. Atorvastatin is eliminated primarily in bile as active metabolites following hepatic and/or extrahepatic metabolism, but does not appear to undergo significant enterohepatic recirculation.
Atorvastatin Preparation Products And Raw materials
Raw materials
Preparation Products
Atorvastatin Suppliers
Global(93)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
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  • Advantage：55
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    career henan chemical co
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  • Supplier：
    Xi'an MC Biotech, Co., Ltd.
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  • Email：mcbio_sales@163.com
  • Country：China
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    sgtlifesciences pvt ltd
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  • Email：dj@sgtlifesciences.com
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Atorvastatin Spectrum
110862-48-1, AtorvastatinRelated Search:
  • Cardiovascular Agents
  • 医药、农药及染料中间体
  • 医药原料药
  • 科研原料
  • 化合物 T22248
  • 阿托伐他汀杂质153
  • (REL)-阿托伐他汀
  • 阿伐他汀/阿托伐他汀
  • 阿伐他汀, ?>98.0%
  • ATORVASTATIN 阿伐他汀
  • 阿托伐他汀(阿伐他汀)
  • (3S,5S)-7-[2-(4-氟苯基)-3-苯基-4-(苯基氨基甲酰基)-5-异丙基吡咯-1-基]-3,5-二羟基庚酸
  • 110862-48-1
  • 7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3，5-dihydroxyheptanoic acid
  • Atorvastatin Impurity 153
  • (rel)-Atorvastatin
  • Atorvastatin isomer
  • calcium 7-[4-[anilino(oxo)methyl]-2-(4-fluorophenyl)-3-phenyl-5-propan-2-yl-1-pyrrolyl]-3,5-dihydroxyheptanoate
  • Atorvastatin, ?>98.0%
  • Atorvastatin(Relative)
  • Atorvastatin
  • (3S,5S)-7-[2-(4-Fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid
  • 1H-PYRROLE-1-HEPTANOIC ACID
  • 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, (βR,δR)-rel-

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