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UCF-101

UCF-101 Structure
UCF-101
  • CAS No.313649-08-0
  • Chemical Name:UCF-101
  • CBNumber:CB7773190
  • Molecular Formula:C27H17N3O5S
  • Formula Weight:495.51
  • MOL File:Mol file
UCF-101 Property
  • Boiling point 651.8±65.0 °C(Predicted)
  • Density 1.50±0.1 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility DMSO: soluble5mg/mL, clear (warmed)
  • pka -0.92±0.20(Predicted)
  • form powder
  • color light orange to dark orange
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Hazard Codes  :T
  • Risk Statements  :25
  • Safety Statements  :45
  • WGK Germany  :3
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301
  • Precautionary statements P264-P270-P301+P310-P321-P330-P405-P501
UCF-101 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1105
  • Product name : UCF-101
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹11528.63
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1105
  • Product name : UCF-101
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹46515.03
  • Updated: 2022/06/14
  • Buy: Buy

UCF-101 Chemical Properties,Usage,Production

  • Description UCF-101 (313649-08-0) is a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, mitochondrial serine protease Omi/HtrA2 (IC50?= 9.5 μM for His-Omi134-458). Shows very little activity against various other serine proteases tested (IC50?≥ 200 μM).1?Mitigates streptozotocin-induced cardiomyocyte dysfunction.2?Protects against cerebral oxidative injury and cognitive impairment in a rat model.3? Cell permeable.
  • Uses UCF 101 is a specific inhibitor of Omi/HtrA2, a proapoptotic mitochondrial serine protease. UCF 101 has the neuroprotective effects on cerebral oxidative injury and cognitive impairment in septic rats.
  • in vitro ucf 101 was identified in a hts of a combinatorial library using omi-(134-458) protease and fluorescein-casein as a generic substrate. ucf 101 exhibited specific activity against omi/htra2 and very little activity against other serine proteases. ucf 101 showed a natural fluorescence that was used to monitor its ability to enter mammalian cells. in addition, when tested in caspase-9 (-/-) null fibroblasts, ucf 101 was able to inhibit omi/htra2-induced cell death [1].
  • in vivo in a previous study, rats were intraperitoneally administered ucf-101 at 1.5 micromol/kg 10 min prior to reperfusion. results showed that ucf-101 treatment could significantly decrease cerebral infarct size by about 16.27% and also improve neurological behavior. moreover, ucf-101 treatment was able to reduce tunel-positive cells in the cerebral cortex significantly. in addition, the upregulation in the expression of fasl and the cleavage products of active caspase-3 and caspase-8 induced by ischemia was attenuated in mice treated with ucf-101, while upregulation of flip levels was increased [2].
  • IC 50 9.5 μm
  • References 1) Cilenti?et al. (2003),?Characteristics of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2; J. Biol. Chem.,?278?11489 2) Li?et al.?(2009),?UCF-101 mitigates streptozotocin-induced cardiomyocyte dysfunction: role of AMPK; Am. J. Physiol. Endocrinol. Metab.,?297?E965 3) Hu?et al.?(2013),?Ucf-101 protects against cerebral oxidative injury and cognitive impairment in septic rat; Int. Immunopharmacol.,?16?108
UCF-101 Preparation Products And Raw materials
Raw materials
Preparation Products
UCF-101 Suppliers
Global(65)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
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    Aladdin Scientific
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  • Supplier： J & K SCIENTIFIC LTD.
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  • Supplier： BOC Sciences
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UCF-101 Spectrum
313649-08-0, UCF-101Related Search:
  • 抑制剂
  • C27H17N3O5S
  • 化合物UCF 101,10 MM DMSO 溶液
  • 5-((5-(2-硝基苯基)呋喃-2-基)亚甲基)-1,3-二苯基-2-硫代二氢嘧啶-4,6(1H,5H)-二酮
  • 化合物UCF 101
  • 313649-08-0
  • UCF 101, 10 mM in DMSO
  • 5-((5-(2-Nitrophenyl)furan-2-yl)methylene)-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
  • Omi,red,Ucf-101,UCF 101,inhibit,pro-apoptotic,543,HtrA2,MI/R,Inhibitor,cardioprotective,His-Omi,Apoptosis,neuroprotective,protease,Ucf101,fluorescence
  • 4,6(1H,5H)-Pyrimidinedione, dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-
  • 5-[[5-[2-(dihydroxyamino)phenyl]furan-2-yl]methylidene]-1,3-diphenyl-2-sulfanylidene-1,3-diazinane-4,6-dione
  • Omi/HtrA2 Protease Inhibitor, Ucf-101 - CAS 313649-08-0 - Calbiochem
  • 5-[[5-(2-nitrophenyl)furan-2-yl]methylidene]-1,3-diphenyl-2-sulfanylidene-1,3-diazinane-4,6-dione
  • 5-[5-(2-NITROPHENYL)FURFURYLIDINE]-1,3-DIPHENYL-2-THIOBARBITURIC ACID
  • HIGH TEMPERATURE REQUIREMENT A2 INHIBITOR I
  • UCF-101
  • Dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione

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