Description
trans-Chalcone is an open chain flavonoid that may prevent lung and forestomach cancer.
Chemical Properties
Trans-Chalcone is a yellowish crystals. M.P. 58℃. (trans-isomer). M .P. 46℃. (cis-isomer).Sp.Gr. 1.07 (liquid).Insoluble in water, soluble in alcohol (poorly) and oils.
Uses
trans-Chalcone is a positive allosteric modulator of α7 nicotinic acetylcholine receptors and exhibits antioxidant activity.
Definition
ChEBI: Chalcone is a member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group. It has a role as a plant metabolite. It is a member of styrenes and a member of chalcones.
Application
trans-Chalcone was used in the synthesis of cis and trans diphenyl cyclopropane. It was also used in screening of surface adsorbed species of isobutybenzene and 4-isobutylacetophenone on bulk fosfotungstic Wells-Dawson acid (H6P2W18O62.xH2O).
Synthesis Reference(s)
Journal of the American Chemical Society, 104, p. 4724, 1982
DOI: 10.1021/ja00381a058
General Description
trans-Chalcone is an open chain flavonoid that may prevent lung and forestomach cancer.
Biological Activity
trans-Chalcone exhibits antifungal activity against Trichophyton rubrum. It is inhibitor of fatty acid synthase and α-amylase. It induces programmed cell death due to reduced mitochondrial transmembrane potential in Arabidopsis thaliana roots.
Biochem/physiol Actions
trans-Chalcone exhibits antifungal activity against Trichophyton rubrum. It is inhibitor of fatty acid synthase and α-amylase. It induces programmed cell death due to reduced mitochondrial transmembrane potential in Arabidopsis thaliana roots.
Synthesis
Trans-Chalcone is synthesized by condensation of Benzaldehyde with Acetophenone.
